TWIN STUDY OF BIOLOGIC MARKERS FOR PTSD

PTSD 生物标志物的双胞胎研究

• 批准号: 2255021
• 负责人: ROGER K. PITMAN
• 金额: $ 46.93万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2255021
• 关键词: TWIN; STUDY; BIOLOGIC; MARKERS; PTSD

DESCRIPTION (Adapted from applicant's abstract): This project will take advantage of the unique opportunity presented by the Vietnam Era Twin (VET) Registry to evaluate potential biologic markers for familial vulnerability to the development of PTSD. Subjects will include twins discordant for combat exposure. Several know biologic PTSD markers will be evaluated by comparing their presence in the (high-risk) unexposed monozygotic (Mz) co-twins of exposed twins with combat-related PTSd versus the (low-risk) unexposed Mz co- twins of exposed twins without combat-related PTSD. A limited sample of (medium-high-risk) unexposed dizygotic (Dz) co-twins of exposed twins with combat-related PTSD will be recruited in order to test whether any identified familial biologic vulnerability factor for PTSD represents the produce of heredity. An additional aim is to examine susceptibility to mental disorder as a familial, possibly inherited, vulnerability factor for PTSD by performing comprehensive psychodiagnostic interviews on subjects in an design parallel to that employed for the PTSD biologic markers. Another aim is to evaluate potential acquired biologic PTSD signs by comparing exposed PTSD twins versus their unexposed Mz co-twins. Dependent variables will include (a) autonomic and muscular startle responses and their habituation; (b) amplitude of the P3 event-related potential (ERP) component in a target discrimination task; (c) slope of the P2 ERP component as a function f tone intensity in a stimulus intensity modulation experiment; and (d) suppression of salivary cortisol following low-dose oral dexamethasone. Each marker to be studied is non-invasive; can be measured on an ambulatory basis; has been shown in previous, published, peer-reviewed research to significantly differentiate PTSD and non-PTSD subject groups; and is capable of being informed by the data to be obtained in the proposed project. Subjects will be diagnosed by a field psychologist using the Clinician- Administered PTSD Scale, Structured Clinical Interview for DSM-IV, and other instruments. Dependent variables will be measured at a traveling field psychophysiology laboratory set up at a VA Medical Center or Vet Center near the subject's home. Statistical significance will be tested by means of univariate and multivariate analyses of variance and covariance and independent t-tests performed on key groups, and selected subgroups. Results are expected to advance our understanding of the constitutional versus acquired nature of biologic abnormalities in PTSD and the pathogenesis of this disorder. Results will also have implications for the prophylactic screening of persons at high risk for the development of PTSD upon exposure to military combat or other severe stressors.

描述（改编自申请人的摘要）：该项目将采取 利用越南时代双子所提供的独特机会 (VET)评估家族性疾病潜在生物学标志物的登记研究 易患创伤后应激障碍受试者将包括双胞胎 与战斗暴露不协调。一些人知道PTSD的生物标志物 通过比较它们在（高风险）未暴露的 患有战斗相关PTSd的暴露双胞胎的同卵（Mz）共双胞胎 与暴露双胞胎的（低风险）未暴露Mz共双胞胎相比， 与战斗有关的创伤后应激障碍（中-高风险）未暴露的有限样本 患有与战斗有关的创伤后应激障碍的暴露双胞胎的双卵（Dz）双胞胎将 招募以测试是否有任何已识别的家族生物学特征 创伤后应激障碍的脆弱性因素代表了遗传的产物。一个 另一个目的是检查对精神障碍的易感性， 家庭的，可能是遗传的，创伤后应激障碍的脆弱性因素， 对设计中的受试者进行全面的心理诊断访谈 与用于PTSD生物标记物的平行。另一个目的 是通过比较 暴露于创伤后应激障碍的双胞胎和未暴露于创伤后应激障碍的同卵双胞胎。 因变量将包括（a）自主神经和肌肉惊吓 （B）P3事件相关的振幅 潜在的（ERP）成分在目标的歧视任务;（c）斜率 P2 ERP分量作为刺激中音调强度的函数 强度调制实验;和（d）抑制唾液 低剂量口服地塞米松后的皮质醇。每一个标记都是 研究是无创的;可以在流动的基础上进行测量;具有 在以前发表的同行评审研究中显示， 显著区分PTSD和非PTSD受试者组;并且 能够从拟议的 项目 受试者将由现场心理学家使用临床医生- 管理员PTSD量表，DSM-IV的结构化临床访谈， 其他文书。因变量将在一个移动 在退伍军人医疗中心或兽医中心设立的现场心理生理学实验室 在目标家附近。将检验统计学显著性 通过单变量和多变量方差分析， 对关键组进行协方差和独立t检验，并选择 分组。研究结果有望促进我们对 创伤后应激障碍中生物学异常的先天性与后天性 以及这种疾病的发病机制。结果也将有 对高危人群进行预防性筛查的意义 创伤后应激障碍的发展暴露于军事战斗或其他严重的 压力源