How the brain produces speech: Neuronal oscillations to neuromodulation

大脑如何产生言语：神经元振荡到神经调节

• 批准号: DP200100127
• 负责人: Prof Greig de Zubicaray
• 金额: $ 36.98万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-07-10 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200100127
• 关键词: How; brain; produces; speech; Neuronal

Speech is crucial for facilitating human communication through language, yet there is a lack of clarity about where, when and what type of activity occurs in the brain during key stages of production. This project will use intracranial recordings to characterise neuronal oscillations in combination with direct electrical stimulation, functional neuroimaging and non-invasive brain stimulation to establish critical areas and their timecourses with millisecond resolution. The outcome will be a better theoretical account of the brain mechanisms involved in spoken production. The benefit of this new theoretical account will be a better basis for prevention of post-surgical language impairment and neuromodulatory treatments after brain injury.

语言对于促进人类通过语言进行交流至关重要，然而，在生产的关键阶段，大脑中发生的活动在哪里、何时和什么类型尚不清楚。该项目将使用颅内记录来表征神经元振荡，并结合直接电刺激、功能神经成像和非侵入性脑刺激来建立关键区域及其毫秒分辨率的时间进程。这一结果将更好地从理论上解释口语产生所涉及的大脑机制。这一新的理论解释将为脑损伤后语言障碍的预防和神经调节治疗提供更好的依据。