OLIGODENDROCYTE ONTOGENY AND DIFFERENTIATION
少突胶质细胞个体发育和分化
基本信息
- 批准号:2263714
- 负责人:
- 金额:$ 17.72万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1984
- 资助国家:美国
- 起止时间:1984-12-01 至 2000-11-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Myelin is the multilamellar membranous sheath that surrounds axons in the
CNS and the PNS, contributing to fast conduction of nerve impulses by
saltatory conduction. In the CNS, the oligodendrocyte synthesizes,
assembles, and maintains the myelin sheath as a complex anatomical and
functional structure. Each oligodendrocyte extends several processes each
terminating in a myelin sheath. In order to achieve the production and
directional assembly of this large amount of membrane, the cell spatially
organizes its synthetic machinery through the redistribution of its
cytoskeletal elements. This hypothesis will be tested by microscopic
analysis of the distribution of cellular organelles and cytoskeletal
elements in oligodendrocytes at various stages of myelin formation.
Myelin components are regionally distributed within the oligodendrocytes
and the myelin sheath. Thus, the synthesis of myelin requires sorting
mechanisms by which specific myelin components are recognized by the
oligodendrocyte cellular machinery and delivered to the site of myelin
assembly. The sorting of myelin basic protein takes place at the level of
its mRNA, which is transported down the processes to the myelin sheath in
a complex associated with the oligodendrocyte cytoskeleton. We propose to
characterize this complex by the use of in situ hybridization,
immunocytochemistry, E.N. localization, and metabolic inhibitors.
Our long term objectives are to delineate and characterize the various
steps in myelin morphogenesis. A better understanding of the process of
myelin formation, and eventually of myelin maintenance and repair, could
lead to therapies, immunochemical, pharmaceutical, or genetic, for
patients afflicted with demyelinating diseases of the CNS and PNS, such as
multiple sclerosis and Guillain-Barre syndrome, and for patients with
demyelinating conditions following therapeutic irradiation and
chemotherapy or viral infections.
髓磷脂是神经元中包围轴突的多层膜鞘。
中枢神经系统和PNS,有助于神经冲动的快速传导,
跳跃式传导 在中枢神经系统中,少突胶质细胞合成,
组装,并维持髓鞘作为一个复杂的解剖和
功能结构 每个少突胶质细胞都延伸出几个突起
终止于髓鞘。 为了实现生产和
大量的细胞膜的定向组装,
组织其合成机器通过重新分配其
细胞骨架成分 这一假设将通过显微镜进行检验。
细胞器和细胞骨架的分布分析
在髓鞘形成的各个阶段的少突胶质细胞中的元素。
髓鞘成分在少突胶质细胞内呈区域性分布
和髓鞘。 因此,髓鞘的合成需要分选
特定髓鞘成分被神经元识别的机制。
少突胶质细胞的细胞机器和交付的网站髓鞘
组装件. 髓鞘碱性蛋白的分选发生在
它的mRNA,这是运输下来的过程中的髓鞘,
一种与少突胶质细胞骨架相关的复合体。我们建议
通过使用原位杂交来表征该复合物,
免疫细胞化学,E.N.定位和代谢抑制剂。
我们的长期目标是描绘和描述各种
髓鞘形态发生的步骤。 更好地理解这一过程
髓鞘的形成,以及最终的髓鞘维持和修复,
导致免疫化学、药物或遗传疗法,
患有CNS和PNS脱髓鞘疾病的患者,例如
多发性硬化症和格林-巴利综合征,
治疗性照射后的脱髓鞘疾病,
化疗或病毒感染。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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