New laser and mass spectrometry methods for detecting protonation isomers

用于检测质子化异构体的新激光和质谱方法

• 批准号: DP200100065
• 负责人: Prof Adam Trevitt
• 金额: $ 29.55万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-05-02 至 2024-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200100065
• 关键词: New; laser; mass; spectrometry; methods

Mass spectrometry is a major tool for the detection of molecules for understanding disease, pollution control and chemical synthesis. However, intricate differences in molecular structure - vital to chemical function - can confuse detection methods leading to false negatives. This is especially problematic for complex biological samples. Recent breakthroughs in laser-based mass spectrometry methods, combined with ion mobility, now allow detection of subtle yet important structural features. This project aims to exploit these advances by developing new instrumentation and protocols with these enhanced capabilities thus accelerating advances in automated mass spectrometry, improved antibiotic detection and complex biomolecule screening.

质谱仪是检测分子的主要工具，用于了解疾病、污染控制和化学合成。然而，分子结构上错综复杂的差异--对化学功能至关重要--可能会混淆检测方法，导致假阴性。对于复杂的生物样本来说，这尤其是个问题。最近基于激光的质谱学方法的突破，结合离子迁移率，现在可以检测到微妙但重要的结构特征。该项目旨在通过开发具有这些增强能力的新仪器和协议来利用这些进展，从而加速自动化质谱学、改进的抗生素检测和复杂生物分子筛选的进展。