New laser and mass spectrometry methods for detecting protonation isomers

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Mass spectrometry is a major tool for the detection of molecules for understanding disease, pollution control and chemical synthesis. However, intricate differences in molecular structure - vital to chemical function - can confuse detection methods leading to false negatives. This is especially problematic for complex biological samples. Recent breakthroughs in laser-based mass spectrometry methods, combined with ion mobility, now allow detection of subtle yet important structural features. This project aims to exploit these advances by developing new instrumentation and protocols with these enhanced capabilities thus accelerating advances in automated mass spectrometry, improved antibiotic detection and complex biomolecule screening.