ANIMAL FACILITY IMPROVEMENT FOR SMALL RESEARCH PROGRAM

为了适应目前和未来教职员工的显著增长 及其临床、研究和教育项目，贝塞斯达眼科研究所 (BEI)目前正在搬迁到一个更大的，翻新的 设施。这个未来的设施(将于1993年5月占用)将是 显著远离BEI所在的主要医疗中心园区 附属的，我们目前(部分)使用的动物护理设施 用来安置我们的许多研究动物。我们认为，未来 设施应包括一个动物资源设施，可容纳所有 用于当前和未来以动物为基础的研究项目的动物 BEI，这也将为专门的 动物外科手术，手术前后的动物护理，以及 必要的动物观察。目前的提案要求联邦资金 提供以下服务：1)在未来翻新现有空间 为拟议的动物资源设施而建，有助于 改造工程实际总造价的一小部分；2)动物 笼舍采购，以容纳额外的动物安置在 新设施；以及3)采购外科/或设备以支持 专门的动物外科需求，补充现有的设备用于 动物手术程序，并更换现有的必要设备 这一目的将不会从 现有设施。 申请的资金将极大地促进基于动物的研究 目前由UPS和私人基金支持的项目，并将 更正了我们AAALAC认证的动物护理中当前存在的缺陷 方案(特别是在机构间动物运输方面)。 所要求的资金对拟议动物的发展是必不可少的 在这项拨款申请中概述的护理设施。年的当前预算 未来的建筑翻新(基于非联邦资金来自 债券发行)不会适应拟议的设施计划；相反，它 将把建设限制在BEI目前的设施类型， 这(由于本建议书中给出的原因)既不符合我们目前的 或预计的未来需求。

In order to accommodate the current and future marked growth of its faculty and its clinical, research and educational programs, Bethesda Eye Institute (BEI) is currently in the process of relocating to a larger, renovated facility. This future facility (to be occupied by May, 1993) will be significantly removed from the main medical center campus with which BEI is affiliated, and whose animal care facilities we currently (in part) utilize for housing many of our research animals. We propose that the future facility should include an animal resource facility that will house all animals utilized for current and future animal-based research projects at BEI, and that will also provide state-of-the-art capacities for specialized animal surgical procedures, pre- and post operative animal care, and requisite animal observation. The present proposal requests federal funds to provide the following: 1) Renovation of an existing space in the future building for the proposed animal resource facility, contributing to a fraction of the actual overall cost of that renovation project; 2) Animal Cage Procurement to accommodate the additional animals to be housed in the new facility; and 3) Surgical/OR Equipment Procurement to support specialized animal surgery needs, supplement existing equipment utilized in animal surgery procedures, and replace existing requisite equipment for that purpose that will not be transferred to the new facility from the existing facility. The requested funds will greatly facilitate the animal-based research programs currently supported by U.S.P.H.S. and private funds, and will correct noted current deficiencies in our AAALAC-accredited animal care program (particularly with regard to inter-institutional animal transport). The requested funds are essential to the development of the proposed animal care facility outlined in this grant application. The current budget for the future building renovation (based on nonfederal funds derived from a bond issue) would not accommodate the proposed facility plan; rather, it would limit construction to the type of facility currently in place at BEI, which (for reasons given in this proposal) do not meet either our current or projected future needs.