BLRD Research Career Scientist Award Application

BLRD 研究职业科学家奖申请

• 批准号: 10365821
• 负责人: Steven J. Fliesler
• 金额: --
• 依托单位: VA WESTERN NEW YORK HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-10-01 至 2026-09-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10365821
• 关键词: 7-dehydrocholesterol reductase; Ablation; Acoustics; Affect; Afghanistan; Antioxidants; Award; Biochemistry; Biological; Biomedical Research; Blindness; Book Chapters; Brain; Buffaloes; Caring; Categories; Cellular biology; Cerebral cortex; Cholesterol; Cholesterol Homeostasis; Clinical; Collaborations; Communities; Conflict (Psychology); Congenital disorders of glycosylation; Defect; Deficiency Diseases; Development; Devices; Diphosphates; Disease; Dolichol; Educational process of instructing; Enzymes; Equilibrium; Eukaryotic Cell; Exhibits; Explosion; Exposure to; Extramural Activities; Eye; Eye Injuries; Faculty; Foundations; Functional disorder; Funding; Genes; Genetic Diseases; Glial Fibrillary Acidic Protein; Gliosis; Goals; Grant; Grant Review; Human; Human Genetics; Inherited; Injury; Institution; International; International Aspects; Intervention; Investigation; Iraq; Journals; Lateral; Lead; Liquid substance; Medical Students; Mentors; Mission; Modeling; Molecular; Mutation; Nonpenetrating Wounds; Ocular Pathology; Ophthalmology; Participant; Patients; Peer Review; Percussion; Persons; Pharmacology; Photoreceptors; Postdoctoral Fellow; Privatization; Professional Organizations; Proteins; Publications; Publishing; Rattus; Recording of previous events; Regulation; Reporting; Research; Research Personnel; Retina; Retinal Degeneration; Retinitis Pigmentosa; Role; Safety; Science; Scientist; Services; Shock; Site; Smith-Lemli-Opitz Syndrome; Soldier; Source; Sterols; Structure; System; Testing; Therapeutic Intervention; Trauma; Traumatic Brain Injury; Traumatic injury; Tube; United States National Institutes of Health; Universities; Up-Regulation; Veterans; Vision; Vision Disorders; Vision research; Visual; Visual Acuity; Visual Fields; Visual system structure; War; academic standard; blast exposure; career; career development; cell type; cytotoxic; distinguished professor; evidence base; falls; fighting; gene therapy; glycosylation; graduate student; improved; insight; isoprenoid; lectures; legally blind; medical schools; member; mouse model; novel; peer; preservation; prevent; programs; senior faculty; symposium; therapeutic evaluation; therapeutically effective; undergraduate student; visual dysfunction

This is the first competing renewal application for my RCS Award. My lab has been engaged in the field of eye research for >37 years; I’ve been a tenured full Professor since 1994. Historically, our focus has been on understanding the normal role of cholesterol and related isoprenoid compounds in promoting and preserving the structure and function of the retina. However, more recently (during the RCS Award period), we’ve turned to studies relevant to traumatic injury to the eye and visual system. Eye injuries resulting in compromised or lost vision are among the signature injuries sustained by our Veterans and deployed soldiers engaged in the recent conflicts in Iraq and Afghanistan (OEF, OIF). Currently, about 170,000 Veterans are legally blind, and nearly 1.5 million have some kind of visual deficit that is battle-related. Traumatic brain injury (TBI) is another signature injury of those conflicts; a significant percentage of TBI patients suffer visual deficits, nearly a third of which are blast-induced. My lab’s goal is to understand the molecular and cellular mechanisms underlying these kinds of trauma-induced vision loss, and to find practical pharmacological interventions to prevent or retard their progression. Those studies are funded by an ongoing VA MERIT Award. In addition, we’re investigating a form of retinitis pigmentosa (RP59)— a hereditary progressive blinding disorder— about which little is known, initially in an effort to understand the causes of the associated retinal degeneration at the molecular level and eventually to develop gene therapy approaches to ameliorate or prevent the degeneration and vision loss. Those studies are supported by an ongoing NEI/NIH R01 grant award. I’ve been a VA Research Service staff member at the Buffalo VAMC since July, 2008, and an RCSA recipient since April, 2016. I hold a tenured endowed chair Professorship and am Vice-Chair/Director of Research in the Dept. of Ophthalmology at the affiliated university (SUNY- University at Buffalo (UB)). I am the only person in the history of my department to become a UB Distinguished Professor and a SUNY Distinguished Professor, and I am the sole RCSA recipient at my VA site. Over the years, I’ve been fortunate to have numerous, productive collaborations, both with VA and non-VA researchers, including current, ongoing projects, and have a strong history of extramural grant funding. I’ve authored or coauthored 129 peer-reviewed publications (+2 in press, + 2 under review)— 38% of which have been published since I joined the VA— plus 10 book chapters and 242 conference abstracts. I’ve given 241 invited lectures (120 while on VA staff) at other universities and research institutions, plus 65 platform presentations (15 while on VA staff) at biomedical research conferences, nationally and internationally. I’ve engaged in multiple service activities— to the VA (local and national), my university, and the broader research community— including service on VA, NIH, DOD (CDMRP), and private foundation grant review panels. I also serve on the Scientific Advisory Board of Foundation Fighting Blindness (FFB). I’ve been elected President of the two leading international eye and vision research professional societies (ARVO and ISER), and serve as Editor-in-Chief of one of the top two eye research journals (Exp. Eye Res.), as well as serving as a peer reviewer for >4 dozen journals. I teach actively in the Biomedical Sciences Graduate Program of my university, both on scientific topics (Cell Biology and Biochemistry) as well as Responsible Conduct in Research. I’ve mentored numerous undergraduate, graduate, and medical students, as well as postdocs and Ophthalmology Residents in my lab (currently: 2 postdocs, 1 medical student, 1 undergrad). I also actively mentor all junior faculty in my own department (including 2 at my VA site), as well as 22 in other departments within the UB Jacobs School of Medicine and Biomedical Sciences, to assist them in their career development. In addition, I’ve been an active participant in the ARVO Global Mentoring Program, and serve on the ASCB International Affairs Committee. Overall, my research, teaching, and service activities meet or exceed the academic standards of my university and also are fully consistent with the VA HSR&D’s mission and the CRADO’s cross-cutting clinical priorities.

这是我的 RCS 奖的第一个竞争性续展申请。我的实验室一直从事眼科领域 研究>37年；自 1994 年以来，我一直是一名终身教授。从历史上看，我们的重点一直是 了解胆固醇和相关类异戊二烯化合物在促进和维护胆固醇方面的正常作用 视网膜的结构和功能。然而，最近（在 RCS 奖期间），我们转向 与眼睛和视觉系统外伤相关的研究。眼睛受伤导致受损或丢失 视力是我们的退伍军人和部署的士兵在最近的战斗中遭受的标志性伤害之一 伊拉克和阿富汗冲突（OEF、OIF）。目前，约有 170,000 名退伍军人在法律上失明，近 1.5 数百万人患有某种与战斗有关的视觉缺陷。创伤性脑损伤 (TBI) 是另一个特征 这些冲突造成的伤害；很大一部分 TBI 患者患有视力障碍，其中近三分之一患有视力障碍 爆炸引起的。我实验室的目标是了解这些类型背后的分子和细胞机制 创伤引起的视力丧失，并找到实用的药物干预措施来预防或延缓其视力丧失 进展。这些研究由正在进行的 VA MERIT 奖资助。此外，我们正在调查一份表格 视网膜色素变性 (RP59)——一种遗传性进行性致盲疾病——最初人们对此知之甚少 努力在分子水平上了解相关视网膜变性的原因，并最终 开发基因治疗方法来改善或预防退化和视力丧失。那些研究 得到正在进行的 NEI/NIH R01 拨款资助。我曾是 VA 研究服务中心的一名工作人员 自 2008 年 7 月起成为 Buffalo VAMC，自 2016 年 4 月起成为 RCSA 获得者。我拥有终身捐赠主席 附属大学眼科教授、副主任/研究主任 （纽约州立大学 - 布法罗大学 (UB)）。我是我们部门历史上唯一一位成为 UB 的人 杰出教授和纽约州立大学杰出教授，我是我所在的 VA 站点唯一的 RCSA 获得者。 多年来，我很幸运能够与 VA 和非 VA 进行大量富有成效的合作 研究人员，包括当前、正在进行的项目，并且拥有悠久的校外资助历史。我已经 撰写或合着 129 篇同行评审出版物（+ 2 篇已出版，+ 2 篇正在审稿）——其中 38% 自从我加入 VA 以来，已出版了 10 本书，还有 10 本书章节和 242 篇会议摘要。我已经给了241 受邀在其他大学和研究机构进行讲座（VA工作人员期间120场），以及65个平台 在国内和国际生物医学研究会议上发表演讲（在 VA 工作人员期间进行了 15 次演讲）。我已经 从事多种服务活动——为退伍军人管理局（地方和国家）、我的大学和更广泛的研究 社区——包括为 VA、NIH、DOD (CDMRP) 和私人基金会拨款审查小组提供服务。我也 在抗盲基金会 (FFB) 科学顾问委员会任职。我被选为主席 两个领先的国际眼科和视力研究专业协会（ARVO 和 ISER），并作为 两大眼科研究期刊之一（Exp. Eye Res.）的主编，并担任同行评审员 超过 4 打期刊。我在我大学的生物医学科学研究生项目中积极教学 科学主题（细胞生物学和生物化学）以及负责任的研究行为。我辅导过 许多本科生、研究生和医学生，以及博士后和眼科住院医师 在我的实验室（目前：2 名博士后、1 名医学生、1 名本科生）。我还积极指导我的所有初级教师 自己的部门（包括我的 VA 站点的 2 个），以及 UB Jacobs 学院其他部门的 22 个 医学和生物医学科学，协助他们的职业发展。另外，我一直是一个活跃的 参加 ARVO 全球指导计划，并在 ASCB 国际事务委员会任职。 总体而言，我的研究、教学和服务活动达到或超过了我所在大学的学术标准 并且也完全符合 VA HSR&D 的使命和 CRADO 的跨领域临床优先事项。