FUNCTIONAL NEUROANATOMY OF MOVEMENT DISORDERS

运动障碍的功能神经解剖学

• 批准号: 2264159
• 负责人: LUCY L BROWN
• 金额: $ 23.97万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-09 至 1996-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2264159
• 关键词: FUNCTIONAL; NEUROANATOMY; MOVEMENT; DISORDERS

Much of the pathophysiology of Parkinson's disease and other movement disorders has been localized to the basal ganglia, especially striatum. The proposed experiments will investigate the anatomical substrate of functional activity in striatum. Normal striatal function is dependent upon widespread cortical innervation of an intrinsic chemoarchitectonic organization of "patches" in a surrounding "matrix" of neurochemicals and receptors, some known to be deficient in movement disorders. However, little is known about the functional role of corticostriate activity within these compartments, except that it may integrate information to select and guide movement. In recent studies using 14C deoxyglucose and somatosensory stimulation, this laboratory has shown that the striatum contains a complex somatotopic map. Three-dimensional analysis reveals that representation of each body region shifts relative to others, in the anteroposterior plane, suggesting that the map is combinational. Another important characteristic of the map is that both sides of the body are represented on each side of the striatum. This presents a new picture of striatal organization. The goals of the present project are 1) to determine the spatial organization of projections from somatosensory cortex to striatum and how that organization relates to the functional activity we have already mapped, 2) to determine the correspondence between sensory and motor cortex projections in striatum and 3) to determine how the body may in striatum is related to its known chemoarchitecture. Methods will include 14C deoxyglucose autoradiography; anterograde anatomical tract tracing with Phaseolus vulgaris-leucoagglutinin, which allows small injection sites and high resolution of axon terminals, and 3H amino acids; electrophysiological recording and stimulation in cortex to physiologically identify the tracer injection sites; mu opiate receptor autoradiography; and tactile stimulation of different body regions, in rats. The hypotheses are that the functional map we described reflects the anatomical projections from cortex, and that the map is principally within the "matrix" compartment, thus defining some of its other inputs and neuroactive substances. The proposed studies swill provide new information about the anatomical, spatial organization of the striatum, at higher resolution than has previously been available. A functional probe of that organization will be useful for future studies of striatal neurochemistry and pathology.

帕金森病和其他运动的大部分病理生理学 疾病局限于基底神经节，尤其是纹状体。 拟议的实验将研究的解剖学基础 纹状体的功能活动。 正常纹状体功能取决于 基于内在化学结构的广泛皮质神经支配 在周围的神经化学物质“矩阵”中组织“补丁” 受体，其中一些已知在运动障碍中存在缺陷。 然而， 关于皮质纹状体活动的功能作用知之甚少 在这些隔间内，除了它可以将信息集成到 选择并引导运动。 在最近的研究中，使用 14C 脱氧葡萄糖和 体感刺激，该实验室已表明纹状体 包含复杂的体位图。 三维分析揭示 每个身体区域的表征相对于其他区域发生变化 前后平面，表明该地图是组合的。 其他 该地图的一个重要特征是身体的两侧 代表纹状体的每一侧。 这呈现出一幅新的画面 纹状体组织。 本项目的目标是 1) 确定体感投影的空间组织 皮质到纹状体以及该组织如何与功能相关 我们已经映射的活动，2）确定对应关系 纹状体中的感觉和运动皮层投射之间以及 3) 确定纹状体中的身体如何与其已知的相关 化学结构。 方法将包括 14C 脱氧葡萄糖 放射自显影；使用 Phaseolus 进行顺行解剖道追踪 寻常白细胞凝集素，允许小注射部位和高 轴突末端和 3H 氨基酸的分辨率；电生理学的 记录和刺激皮层以从生理上识别 示踪剂注射部位； mu阿片受体放射自显影；和触觉 刺激大鼠不同的身体区域。 假设是 我们描述的功能图反映了解剖学投影 皮层，并且地图主要位于“矩阵”隔间内， 从而定义了它的一些其他输入和神经活性物质。 这 拟议的研究将提供有关 纹状体的解剖学、空间组织，在较高的 分辨率高于以前可用的分辨率。 的功能探针 该组织将对纹状体的未来研究有用 神经化学和病理学。