MODIFICATION AND CONTROL OF MOTOR SYSTEM FUNCTION

该项目的目的是进行一系列的合作， 研究项目集中在其主题，“修改和控制电机 系统功能”。该计划项目包括四项研究建议， 四个核心来实现这一目标。 建议1和2利用了 新开发的多个单单元记录技术，允许 同时记录特定中枢的8到12个神经元 在获得各种类型的条件反射行为的过程中。 建议一侧重于经典条件反射的神经基质 家兔的瞬膜反应。 建议2中的实验 研究小脑系统在两种类型的习得中的作用。 条件性行为：运动的条件性改变， 慢性病猫的操作性条件性伸手行为。 提案3还 专注于小脑和脑干系统，特别是解决 猫下橄榄核反应的行为改变 执行特定的运动行为。 的功能特性 脊髓反射系统在提案4中得到了解决。 这些实验 检查足和踝关节的节段和棘上控制。 这些 项目汇集了高度互动的教师谁将分享他们的 专业知识，以解决这些研究目标，在一个非常全面的 方式 预计拟议研究的结果不仅 将提供实质性的洞察的方式，具体组成部分的 运动系统有助于任务获得和运动性能，但也 将揭示神经元群体变化的有趣见解 运动学习过程中的反应，门控机制的特点， 在运动行为过程中发生，以及下降之间的相互作用， 系统和节段脊髓反射有关的后肢。 程序 项目的组织方式是优化的增长， 参与教师之间的互动和他们的质量 研究项目。 它将在一个环境中管理， 高度致力于临床和基础科学的培训，并将 作为与其他司进行正式和非正式接触的重点， 研究所和区域学术界和科学界。

The purpose of this Program Project is to conduct a series of collaborative research projects focused on its theme, "Modification and Control of Motor System Function". The Program Project contains four research proposals and four cores to address this objective. Proposals 1 and 2 utilize a newly-developed multiple single-unit recording technique that permits the simultaneous recording of eight to twelve neurons in specific central nuclei during the acquisition of various types of conditioned behavior. Proposal I focuses on the neural substrates of the classical conditioned nictitating membrane response in the rabbit. The experiments in Proposal 2 examine the role of cerebellar systems in the acquisition of two types of conditioned behavior: a conditioned modification of locomotion and an operantly-conditioned reaching behavior in chronic cats. Proposal 3 also focuses on cerebellar and brainstem systems, specifically addressing the behavioral modification of cat inferior olivary responses during the execution of specific motor behaviors. The functional characteristics of spinal reflex systems is addressed in Proposal 4. These experiments examine the segmental and supraspinal control of the foot and ankle. These projects bring together a highly interactive faculty who will share their expertise to address these research objectives in a very comprehensive manner. It is expected that the results from the proposed studies not only will provide substantial insight into the way specific components of the motor system contribute to task acquisition and motor performance, but also will reveal intriguing insights into the changes in neuronal population responses during motor learning, the characteristics of gating mechanisms occurring during motor behavior, and the interaction between descending systems and segmental spinal reflexes related to the hindlimb. The Program Project is organized in a manner that optimizes the growth of the interactions among the participating faculty and the quality of their research programs. It will be administered in an environment that is highly dedicated to training in the clinical and basic sciences and will serve as a focus for formal and informal interfaces with other divisions in the Institute and the regional academic and scientific community.