MODIFICATION AND CONTROL OF MOTOR SYSTEM FUNCTION

本计划项目的目的是进行一系列协作 研究项目主要围绕其主题--《电机的改造与控制》 该计划项目包含四项研究建议和 解决这一目标的四个核心。提案1和2利用 新开发的多个单单元记录技术，允许 同时记录特定中枢8~12个神经元 核团在获得各种类型的条件性行为时。 建议I集中在经典条件反射的神经基础上 兔的瞬膜反应。提案2中的实验 研究小脑系统在获得两种类型的 条件性行为：运动和行为的条件性修改 慢性猫科动物的操作条件性触达行为。提案3还 重点关注小脑和脑干系统，特别是解决 猫下橄榄核反应的行为学改变 执行特定的运动行为。的功能特点 建议4涉及脊髓反射系统。这些实验 检查足部和脚踝的节段性和棘上控制性。这些 项目将高度互动的教职员工聚集在一起，他们将分享他们的 在非常全面的情况下解决这些研究目标的专业知识 举止。预计拟议研究的结果不仅是 将提供对特定组件如何使用 运动系统有助于任务获得和运动表现，但也 将揭示对神经元数量变化的耐人寻味的见解 运动学习中的反应，门控机制的特点 发生在运动行为过程中，与下行之间的相互作用 与后肢相关的系统和节段性脊椎反射。该计划 项目的组织方式优化了 参与教师之间的互动和他们的质量 研究项目。它将在以下环境中进行管理 高度致力于临床和基础科学的培训，并将 作为与其他部门的正式和非正式接口的重点 研究所以及区域学术和科学界。

The purpose of this Program Project is to conduct a series of collaborative research projects focused on its theme, "Modification and Control of Motor System Function". The Program Project contains four research proposals and four cores to address this objective. Proposals 1 and 2 utilize a newly-developed multiple single-unit recording technique that permits the simultaneous recording of eight to twelve neurons in specific central nuclei during the acquisition of various types of conditioned behavior. Proposal I focuses on the neural substrates of the classical conditioned nictitating membrane response in the rabbit. The experiments in Proposal 2 examine the role of cerebellar systems in the acquisition of two types of conditioned behavior: a conditioned modification of locomotion and an operantly-conditioned reaching behavior in chronic cats. Proposal 3 also focuses on cerebellar and brainstem systems, specifically addressing the behavioral modification of cat inferior olivary responses during the execution of specific motor behaviors. The functional characteristics of spinal reflex systems is addressed in Proposal 4. These experiments examine the segmental and supraspinal control of the foot and ankle. These projects bring together a highly interactive faculty who will share their expertise to address these research objectives in a very comprehensive manner. It is expected that the results from the proposed studies not only will provide substantial insight into the way specific components of the motor system contribute to task acquisition and motor performance, but also will reveal intriguing insights into the changes in neuronal population responses during motor learning, the characteristics of gating mechanisms occurring during motor behavior, and the interaction between descending systems and segmental spinal reflexes related to the hindlimb. The Program Project is organized in a manner that optimizes the growth of the interactions among the participating faculty and the quality of their research programs. It will be administered in an environment that is highly dedicated to training in the clinical and basic sciences and will serve as a focus for formal and informal interfaces with other divisions in the Institute and the regional academic and scientific community.