A nanodiamond voltage sensor: towards real-time, long-term neuronal sensing

纳米金刚石电压传感器：实现实时、长期神经元传感

• 批准号: DE200100279
• 负责人: Dr Philipp Reineck
• 金额: $ 29.78万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-08-20 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE200100279
• 关键词: nanodiamond; voltage; sensor; towards; real

This project aims to develop a voltage sensor that may ultimately be used to measure neuronal signals noninvasively in real-time and over hours. The project expects to generate the fundamental science needed to use nanodiamonds for fluorescence-based voltage sensing that can be easily measured using optical microscopy. The expected outcome is a biocompatible sensor that should provide a solution to one of the biggest challenges in neuroscience; the fast, precise and long-term measurement of neuronal activity. This technology may one day inform our understanding of how the normal brain works and provide major insights into mental health conditions and neurodegenerative diseases.

该项目旨在开发一种电压传感器，最终可用于实时和数小时无创测量神经元信号。该项目预计将产生使用纳米金刚石进行基于荧光的电压传感所需的基础科学，可以使用光学显微镜轻松测量。预期的结果是一种生物相容性传感器，应该为神经科学中最大的挑战之一提供解决方案;快速，精确和长期测量神经元活动。这项技术有一天可能会让我们了解正常大脑是如何工作的，并为心理健康状况和神经退行性疾病提供重要见解。