Improving disease resilience in ecosystems using synthetic biology

利用合成生物学提高生态系统的疾病恢复能力

• 批准号: FT190100462
• 负责人: Prof Lee Skerratt
• 金额: $ 64.39万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-05-08 至 2024-05-07
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT190100462
• 关键词: Improving; disease; resilience; ecosystems; using

This project aims to use the latest methods in synthetic biology to conserve species threatened by disease, through characterising and enhancing immunity. Emerging infectious diseases are a major threat to ecosystems and new methodologies are needed to fight them. Chytridiomycosis is the most devastating disease of vertebrates, causing population declines in over 200 amphibian species worldwide. The expected outcomes of the project are improved understanding and increased immunity of frogs to chytridiomycosis and restoration of frogs into the environment. The project will demonstrate the usefulness of synthetic biology to tackle disease and preserve biodiversity in the landscape for similarly threatened wildlife in Australia and overseas.

该项目旨在使用合成生物学的最新方法，通过表征和增强免疫力来保护受到疾病威胁的物种。新出现的传染病是对生态系统的重大威胁，需要新的方法来抗击它们。棘霉病是脊椎动物中最具破坏性的疾病，导致全球200多种两栖动物的种群数量下降。该项目的预期结果是改善对青蛙的了解，提高青蛙对棘球菌病的免疫力，并使青蛙恢复到环境中。该项目将展示合成生物学在应对疾病和保护澳大利亚和海外类似受威胁野生动物景观中的生物多样性方面的有效性。