NEONATAL LEAD EXPOSURE EFFECTS ON THE ADRENAL CORTEX FUNCTION

新生儿铅暴露对肾上腺皮质功能的影响

• 批准号: 3755895
• 负责人: KARAM F A SOLIMAN
• 金额: --
• 依托单位: FLORIDA AGRICULTURAL AND MECHANICAL UNIV
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3755895
• 关键词: adrenal glands; adrenocorticotropic hormone; atomic absorption spectrometry; blood glucose; corticosterone; endocrine disorder; glucocorticoids; glycogen; high performance liquid chromatography; hormone receptor; hypothalamic pituitary axis; iodine; laboratory rat; lead poisoning; neurotransmitters; newborn animals; pharmacokinetics; radionuclides; stress

The disruptive effects of elevated lead levels on the functioning of developing hypothalamic-pituitary-adrenal axis (HPAA) has not been well examined. The purpose of this research investigation is to examine the effect of lead exposure on the ontogeny of HPAA function. In this investigation, Sprague-Dawley rats will be administered lead at postnatal day (PND) 1 until PND 21. Blood levels of lead in neonatally exposed animals and their control will be monitored. All animals will be assessed and evaluated at PND 21, 35 and 120 for the adrenal function using different experimental paradigms. In one experiment we will examine the effect of lead exposure on the function of the hypothalamus, pituitary and the adrenal gland. In another experiment we will evaluate the adrenocortical function of lead treated animals by evaluating basal levels of corticosterone, ACTH, glucocorticoid receptors, hypothalamic biogenic amines, plasma glucose levels and liver glycogen. We will also examine the effect of acute and chronic stress on the hormonal profile of these animals. In a final experiment we will evaluate the toxic effect of lead on the maturation of the adrenal cortex. The outcome of this research should help in the understanding of how neonatal exposure to lead can modify the adrenal cortical function.

高铅水平对脑功能的破坏性影响