OSTEOPONTIN--ROLE IN CELL ATTACHMENT AND SIGNALING

骨桥蛋白——在细胞附着和信号传导中的作用

• 批准号: 2082316
• 负责人: DAVID T DENHARDT
• 金额: $ 1.4万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-01 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2082316
• 关键词: binding proteins; biological signal transduction; cell adhesion; integrins; meeting /conference /symposium; phosphoproteins; protein structure function; travel

This meeting on osteopontin (OPN, an integrin-binding secreted phosphoprotein) is intended to bring together investigators who do not normally interact because they are interested in different disciplines that normally meet separately. By means of this conference we expect to acquire new insights into OPN 's role in human development, physiology, and pathology. Major foci of OPN research include its role in tissue mineralization, in calcium homeostasis, in cell signalling, in cell attachment, and in nonspecific immunity. OPN is produced by cells that generate or remodel mineralized matrix: it promotes cell attachment to hydroxyapatite via its RGD alpha-v-beta3-binding domain and is involved in bone formation, bone remodeling and stone formation. OPN is likely important in defending against certain infections, particularly rickettsia and gram negative organisms. It is expressed at high levels by many types of cancer cells, and recent evidence suggests that its importance to the tumor cell may reside in its ability to suppress nitric oxide production. OPN expression correlates with smooth muscle migration and it is implicated in the development of atherosclerotic lesions and restenosis after angioplasty. It is found in most if not all secreted body fluids, and in some (urine, bile and milk) it may be critical to the suppression of the precipitation of calcium salts. OPN is found in cochlear fluid and may play a role there in calcium homeostasis. OPN is found in certain neurons, where it may be involved in some aspect o regulating signal transduction via nitric oxide. In the decidua and placenta it could mediate calcium transport between fetal and maternal tissues. OPN up- regulation in hypoxic cells suggests a role in shielding against ischemic injury, perhaps because of its ability to bind calcium. Prominent investigators working in these different areas have agreed to participate, and young investigators new to the field will be invited to present their research in poster format. To our knowledge there are no meetings scheduled that overlap with this proposed conference. Appended is the proposed agenda for this two-day meeting.

这次关于骨桥丁的会议（OPN，整合性结合分泌的会议 磷蛋白）的目的是将没有的调查员聚集在一起 通常互动是因为他们对不同学科感兴趣 通常会分开相遇。通过这次会议，我们希望 获得有关OPN在人类发展，生理学中的作用的新见解， 和病理。 OPN研究的主要焦点包括其在组织中的作用 矿化，在钙稳态中，在细胞信号传导中，在细胞中 附着，并以非特异性免疫力。 OPN由细胞产生 生成或重塑矿化矩阵：它促进细胞附着 羟基磷灰石通过其RGD alpha-v-beta3结合域，参与 骨形成，骨骼重塑和石材形成。 OPN可能是 对于防御某些感染，尤其是立克的重要性很重要 和革兰氏阴性生物。它以许多类型的高度表达 癌细胞和最近的证据表明，其对 肿瘤细胞可能存在于其抑制一氧化氮产生的能力。 OPN表达与平滑肌迁移相关，这是 与动脉粥样硬化病变和再狭窄的发展有关 血管成形术后。在大多数分泌的体液中发现它， 在某些（尿液，胆汁和牛奶）中，这可能对抑制至关重要 钙盐的沉淀。在人工耳蜗中发现了OPN，并且 可能在钙稳态中发挥作用。 在某些地方发现了OPN 神经元，它可能参与某个方面o调节信号 通过一氧化氮转导。在Decidua和胎盘中可以 介导胎儿和母体组织之间的钙转运。 opn向上 - 低氧细胞中的调节表明在屏蔽缺血性中起作用 受伤，也许是因为它具有结合钙的能力。著名的 在这些不同领域工作的调查人员已同意参加 新手的年轻调查员将被邀请介绍他们的 海报格式的研究。据我们所知，没有会议 计划与此拟议的会议重叠。附加是 为期两天的会议提议议程。