GORDON CONFERENCE ON EXCITATION/CONTRACTION COUPLING

戈登兴奋/收缩耦合会议

• 批准号: 2082007
• 负责人: GERHARD W MEISSNER
• 金额: $ 1.45万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-06-01 至 1995-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2082007
• 关键词: calcium channel; calcium transporting ATPase; meeting /conference /symposium; muscle contraction; muscle function; travel

The proposed conference on Muscle:Excitation-Contraction (E-C) Coupling is scheduled for July 3-8,1994, at Tilton School, New Hampshire, under the sponsorship of the Gordon Research Conferences. The last conference on this subject was held in 1991. The timing of the current conference is particularly appropriate in view of the recent convergence of physiological, biophysical, and molecular biological approaches in determining the molecular properties of the components of E-C coupling, their assembly and regulation in muscle as well as nonmuscle tissues. Themes to be developed include the following: Ca2+ homeostasis and plasmalemmal ion permeability in normal muscle and muscle diseases; structure and regulatory mechanisms of the sarco/endoplasmic reticulum Ca2+ pump; structure and assembly of E-C coupling components; voltage control of Ca2+ release in skeletal muscle; regulation of Ca2+ release by putative endogenous Ca2+ mobilizing agents (Ca2+, lP3, cyclic ADP-ribose, etc.) in muscle and nonmuscle preparations; application of modern imaging techniques to the measurement of intracellular [Ca2+] in muscle and non muscle cells; and molecular approaches to studying structure-function relations of dihydropyridine, ryanodine and lP3 receptor/Ca2+ channels. Oral presentations of posters by young investigators will take place at the end of each session. The conference will be divided into nine sessions with scheduled session leaders, speakers and discussants, poster sessions and discussion time. The Gordon Conference's on E-C coupling have a highly successful history of bringing together active investigators from all over the world in a format which encourages free and informal exchange of ideas and unpublished data. The open discussion of ongoing work is valuable at this time in the E-C coupling field because recent advances have opened up new avenues of investigation. No other conference bringing together such a wide range of expertise in this area of research is planned in the near future.

拟议的肌肉会议：激发反应（E-C）耦合是 定于1994年7月3日至8日，在新罕布什尔州的蒂尔顿学校 戈登研究会议的赞助。最后一次会议 该主题于1991年举行。当前会议的时机是 鉴于最近的融合，特别适合 生理，生物物理和分子生物学方法 确定E-C耦合成分的分子特性， 它们在肌肉以及非肌肉组织中的组装和调节。 要开发的主题包括以下内容：CA2+稳态和 正常肌肉和肌肉疾病中的浆离离子渗透性； 肉体/内质网的结构和调节机制 Ca2+泵； E-C耦合组件的结构和组装；电压 控制骨骼肌中Ca2+释放；调节Ca2+释放 推定的内源性CA2+动员剂（Ca2+，LP3，环状ADP-核糖， 等）在肌肉和非肌肉制剂中；现代成像的应用 肌肉和非细胞内[Ca2+]测量的技术 肌肉细胞；研究结构功能的分子方法 二氢吡啶，ryanodine和LP3受体/Ca2+通道的关系。 年轻调查人员的海报口头演讲将在 每个会话结束。 会议将分为9次会议 领导者，演讲者和讨论者，海报会议和讨论时间。 Gordon会议上有关E-C耦合的会议具有非常成功的历史 将来自世界各地的活跃调查员聚集在一起 鼓励自由和非正式交流思想的格式和 未发表的数据。关于正在进行的工作的公开讨论对此很有价值 在E-C耦合领域的时间，因为最近的进步已经开放了新的 调查途径。没有其他会议将这样的 计划在该领域的研究中广泛的专业知识。 未来。