JOINT CONFERENCE ON ENDOTHELIAL CELL AND ATHEROSCLEROSIS

动脉粥样硬化相关疾病的发病机制 炎症是由各种细胞之间的相互作用统一起来的 分子成分和内皮细胞。在悬而未决的 在动脉粥样硬化形成和炎症方面的问题正在被理解 分子水平：破坏正常血管的细胞变化 动态平衡或导致不适当的迁移和激活 炎性细胞和血管壁源性细胞。这两次会议是， 因此，显然统一于他们对作用的多样性的关注 血管与影响血管的各种因素的相互作用 在正常和致病状态下。这些交互包括 不同生长介质对血管细胞增殖的影响 与炎症有关的各种细胞和分子相互作用 以及由此导致的动脉粥样硬化，即与血液有关的黏附分子 细胞-内皮相互作用及血管活性因子在血管内皮细胞损伤中的作用 血管内皮细胞的功能，仅举几例。这两次会议将带来 来自多个领域的大量调查合而为一 论坛讨论了各种各样的话题。此外，演讲者还将 包括对我们的调查做出重大贡献的调查人员 了解细胞的基本功能(细胞器移位和 贩运、细胞信号级联、翻译后控制等) 通常不会参加这次会议的人，因为它的生物 透视。因此，这些讨论不仅将导致 提出修改后的假设，但它们也将导致 发展新的合作和潜在的新疗法 以及用于治疗大量疾病的诊断工具 与动脉粥样硬化和炎症有关。

The pathogenic mechanisms underlying diseases related to atherogenesis and inflammation are unified by the interactions between various cellular and molecular components and the endothelium. Among the unresolved issues in both atherogenesis and inflammation are understanding at the molecular level the cellular changes that either disrupt normal vascular homeostasis or that result in the inappropriate migration and activation of inflammatory and vessel wall-derived cells. These two meetings are, thus, clearly unified by their focus on the role of the diversity of interactions between the blood vessel and various factors affecting it during normal and pathogenic states. These interactions include the affects of various growth mediators on vessel cell proliferation, the various cellular and molecular interactions involved with inflammation and resultant atherogenesis, the adhesion molecules involved with blood cell-endothelial interactions, and the role of vasoactive factors in endothelial cell function, to name a few. These two meetings will bring a large number of investigations from numerous fields together in one forum to discuss a diversity of topics. In addition, speakers will include investigators who have significantly contributed to our understanding of basic cellular functions (organelle translocation and trafficking, cell signaling cascades, post-translational controls, etc.) and who would normally not attend this conference because of its biologic perspective. Thus, these discussions will not only result in the formulation of modified hypotheses, but they will also result in the development of both new collaborations and potentially new therapeutic and diagnostic tools for the treatment of the large numbers of diseases associated with atherogenesis and inflammation.