MRI: Acquisition of a High-throughput Flow Cytometry for Health Science Research and Training

该主要研究仪器奖支持宾厄姆顿大学获得高性能、高通量和多色荧光细胞分析仪。该仪器的收购将有助于宾厄姆顿大学的研究人员在再生医学、药物输送、癌症早期诊断、3D生物打印、肌肉萎缩症相关的多细胞病变、癌症免疫治疗的癌症疫苗配方和抗癌药物的高通量筛选方面开展新技术的研究。这些研究将推动组织工程、药理学、再生医学、细胞生物学、药物发现和蛋白质科学等领域的发展。这种增加的研究基础设施将促进教育项目中的更多合作，并将加强一些生物和健康科学课程。将开设新的课程和讲习班，为研究生和本科生提供新的教育和培训机会。一年一度的校园开放日活动将举行，以接触到K-12学生和当地社区，特别是那些来自代表性不足的群体。多色荧光细胞分析仪将配置5个激光器，覆盖从紫外到红外的波长，可同时检测23种不同的颜色。其高通量配置将允许在15分钟内自动完成96孔板分析，并且从一个孔到下一个孔的样品携带量小于0.5%。这些新功能的增加将使宾厄姆顿大学的研究人员能够追求新的研究方向，并扩大他们的研究和教育项目。此外，收购细胞分析仪将促进宾厄姆顿大学与医院和行业的合作，加速将健康科学发现转化为商业产品。通过该项目进行的研究将为对生物系统的基本理解提供新的见解，从而开发改善人类健康的新技术。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This Major Research Instrumentation award supports the acquisition of a high performance, high-throughput, and multicolor fluorescence cell analyzer at Binghamton University. The acquisition of this instrument will help Binghamton University investigators to perform research in developing new technologies for regenerative medicine, drug delivery, cancer early diagnosis, 3D bioprinting, muscular dystrophy associated multicellular lesions, cancer vaccine formulations for cancer immunotherapy, and high-throughput screening of anti-cancer agents. These studies will advance fields such as tissue engineering, pharmacology, regenerative medicine, cell biology, drug discovery, and protein sciences. This added research infrastructure will spur more collaborations in educational programs and will enhance a number of biological and health science courses. New courses and workshops will be developed to provide new education and training opportunities to both graduate and undergraduate students. Annual campus-wide open-house events will be held to reach out to K-12 students and local communities, especially to those from underrepresented groups. The multicolor fluorescence cell analyzer will be configured with five lasers covering wavelengths from UV to infrared for detecting 23 different colors simultaneously. Its high-throughput configuration will allow the automated completion of 96-well plate analysis within 15 minutes and with less than 0.5% sample carryover from one well to the next. The addition of these new capabilities will empower Binghamton University's investigators to pursue new research directions and to expand their research and education programs. Furthermore, the acquisition of the cell analyzer will foster Binghamton University's collaboration with hospitals and industries to accelerate the translation of health science discoveries into commercial products. The studies conducted through this project will offer new insights into fundamental understanding of biological systems, leading to the development of new technologies for improving human health.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.