ANALGESIA AND SPASM CONTROL AFTER SPINAL CORD INJURY

描述（改编自研究者摘要）：在拟定的 研究中，脊髓横断后神经横断将 在大鼠中使用，以检验在女性中的父母补助假设， T12脊髓完全性损伤时， 生殖道（如子宫颈）持续存在，因为下腹和/或 通向大脑的迷走神经通路保持其完整性。 行为上， 刺激阴道子宫颈的自主神经和神经内分泌反应 将在脊髓横断后测量，之后， 将切断腹下神经和/或迷走神经， 确定这些神经是否介导了持续的反应， 脊髓横切 因此，拟议的研究将扩大和 扩大父母补助金，但不重叠。 目前建议是确定是否：a）镇痛反应 阴道颈部刺激将持续高于脊髓水平 在L5或T7横断，阻断了从骨盆和 腹下神经。 我们将确定后续是否 切断双侧腹下神经，然后切断迷走神经， 残余效应，B）自主神经反应，即心率增加 以及瞳孔扩张，对阴道-宫颈刺激的反应将 受脊髓和这些神经横断的影响，c） 催产素的释放对阴道宫颈刺激的反应将是 受脊髓和这些神经横断的影响。 的 本申请是与卡洛斯拜尔合作提出的， 哲学博士、和拉斐尔·奎瓦-罗隆医学博士哲学博士、 他们提供专业知识， 脊髓神经生理学-神经药理学 拟议研究 将提供一个实验性的神经学基础， 解释生殖道刺激的反应， 脊髓完全损伤的妇女在父母补助金。 的证据 迷走神经在介导这些反应中的作用 康复医学的意义，因为它将表明 存在感觉通路，通过该通路来自子宫颈的感觉脉冲 子宫可以直接进入大脑，完全绕过大脑。 脊髓，从而保持功能，即使在妇女谁是 完全瘫痪 拟议的研究将提供一个重要的 有机会正式支持积极的长期合作 这两个研究小组之间存在的研究互动， 美国和墨西哥

DESCRIPTION (adapted from investigator's abstract): In the proposed study, spinal cord transection followed by nerve transection will be utilized in the rat to test the parent grant hypothesis that in women with complete spinal cord injury as high as T12, sensibility of the reproductive tract (e.g. cervix) persists because the hypogastric and/or vagus nerve pathways to the brain retain their integrity. Behavioral, autonomic and neuroendocrine responses to vaginocervical stimulation will be measured after spinal cord transection, after which they hypogastric and/or vagus nerves will be transected, in order to ascertain whether these nerves mediate the responses that persist after the spinal cord transection. Thus, the proposed study would extend and expand the parent grant without overlapping it. The specific aims of the current proposal are to ascertain whether: a) Analgesia in response to vagino-cervical stimulation will persist above the level of spinal transection at L5 or T7, which blocks ascending pathways from pelvic and hypogastric nerves, respectively. We will ascertain whether subsequent bilateral transection of hypogastric and then vagus nerves will block and residual effects, b) Autonomic responses, i.e. increases in heart rate and pupil dilatation, in response to vagino-cervical stimulation will be affected by the transections of spinal cord and these nerves, c) Oxytocin release in response to vaginocervical stimulation will be affected by the transections of spinal cord and these nerves. The present application is proposed in collaboration with Carlos Beyer, Ph.D., and Rafael Cueva-Rolon, M.D., Ph.D., who provide expertise in spinal cord neurophysiology-neuropharmacology. The proposed research would provide an experimental neurological foundation on which to base interpretation of the responses to reproductive tract stimulation in women with complete spinal cord injury in the parent grant. Evidence of a role of the vagus nerve in mediating these responses would have significance for rehabilitation medicine, since it would indicate the existence of a sensory pathway via which sensory impulses from the cervix and uterus could enter the brain directly, completely bypassing the spinal cord, and thus remaining functional even in women who are complete tetraplegic. The proposed study would provide a significant opportunity to formally support the active long-term collaborative research interaction that exists between these two research groups in the U.S. and Mexico.