CONFERENCE ON EUKARYOTIC NUCLEUS

细胞核是最大也可能是最复杂的细胞器。 真核细胞。细胞和发育调节的研究， 肿瘤发生和病毒感染日益集中在核上 本地化和指向适当的核内地址 重要的监管要点。尽管分子方面的细节 直到最近，个体核功能才在体外被研究出来。 是否有令人兴奋的研究表明这些函数依赖于 核内的特殊结构。重要的问题包括如何 染色体的构造和组织，核的机制 运输，以及原子核的组装和拆解机制 有丝分裂。其他包括确定组织和职能 核基质和核仁等核结构。最后， 激动人心的问题集中在一个分子的组成和作用 新的和意想不到的核内细胞器的数量也在增加 随着最近发现的核内轨迹，mRNA和蛋白质沿着 分子似乎以定向的方式运动。这次会议的目标是 汇聚核结构各方面的专家， 函数，以便组装 原子核。 会议主题： 1.核包络：结构性观点 2.核运输机制：输入、输出、胞质因子 3.细胞核在细胞周期中的组装和拆解 4.染色质和染色体：组织、转录调控和 染色质 5.着丝粒和端粒 6.DNA复制：基础，与更高阶核的关系 构筑物 7.核域和地址：核仁和多核 新的核内“细胞器” 8.核矩阵：结构和功能 9.RNA剪接和交替剪接：基础，超分子核 剪接用细胞器 10.信使核糖核酸输出

The nucleus is the largest and perhaps most complex organelle of the eukaryotic cell. Studies of cellular and developmental regulation, oncogenesis, and viral infection increasingly converge upon nuclear localization and direction to an appropriate intranuclear address as important points of regulation. Although the molecular details of individual nuclear functions have been worked out in vitro, only recently have exciting studies shown the dependence of these functions on particular structures within the nucleus. Important questions include how chromosomes are constructed and organized, the mechanism of nuclear transport, and the mechanism of assembly and disassembly of the nucleus at mitosis. Others include determining the organization and function of nuclear structures such as the nuclear matrix and the nucleolus. Lastly, exciting questions focus on the molecular composition and roles of an increasing number of new and unexpected intranuclear organelles, as well as recently discovered intranuclear tracks along which mRNA and protein molecules appear to move in a directed manner. The goal of the meeting is to bring together specialists on all aspects of nuclear structure and function in order to assemble a three-dimensional, functional view of the nucleus. SESSION TOPICS: 1. The Nuclear Envelope: A Structural View 2. The Mechanism of Nuclear transport: Import, Export, Cytosolic Factors 3. Assembly & Disassembly of the Nucleus in the Cell Cycle 4. Chromatin & Chromosomes: Organization, Regulation of Transcription, and Chromatin 5. Centromeres and Telomeres 6. DNA Replication: Basics, Relationship to Higher Order Nuclear Structures 7. Nuclear Domains and Addresses: The Nucleolus and Multiple New Intranuclear "Organelles" 8. The Nuclear Matrix: Structure and Function 9. RNA Splicing and Alternate Splicing: Basics, Supramolecular Nuclear Organelles for Splicing 10. mRNA Export