FIFTH INTERNATIONAL WORKSHOP ON HUMAN CHROMOSOME 21

描述：(改编自申请人的摘要)。资金是 要求支持美国参会者前往第五届 人类21号染色体国际研讨会将在筑波举行， 日本。会议原定于6月举行。 1994年15日至17日，但已重新安排在11月9日至11日举行 满足日本东道主的需求。研讨会的总体目标是 将继续制定一份详细的共识图 21号染色体。预计酵母的最小平铺路径 人工染色体(YAC)至少是长(Q)臂的 染色体将在这次研讨会上完成。新词的使用 测绘技术，包括限制性标志性基因组 扫描(RLGS)和RecA辅助的核酸内切酶(RARE)切割 促进21号染色体的作图将得到评估。《创造》 21号染色体的着丝粒和短(P)臂图谱 并对这一努力进行评估将是至关重要的 最大限度地绘制人类基因组的这一重要部分。 在利用新的克隆系统方面的进展，包括P1和 将评估细菌人工染色体(PAC和BAC)系统， 未来21号染色体研讨会的形式也将如此。

DESCRIPTION: (Adapted from the applicant's abstract). Funding is requested to support travel for US participants to the Fifth International Workshop on Human Chromosome 21, to be held in Tsukuba, Japan. Originally, the conference was scheduled to take place June 15-17,1994, but it has been rescheduled for November 9 through 11 to meet the needs of the Japanese host. The overall goal of the workshop will be to continue the development of a detailed consensus map of chromosome 21. It is expected that a minimal tiling path of yeast artificial chromosomes (YACs) for at least the long (q) arm of the chromosome will be completed at this workshop. The use of new technologies for mapping, including restriction landmark genomic scanning (RLGS) and RecA assisted endonuclease (RARE) cleavage for facilitating the mapping of chromosome 21 will be assessed. The creation of a centromere and short (p) arm map of chromosome 21 has been undertaken, and evaluation of this endeavor will be essential to maximize the mapping of this significant fraction of the human genome. Progress in the utilization of new cloning systems, including P1 and bacterial artificial chromosome (PAC and BAC) systems will be assessed, as will the format of future chromosome 21 workshops.