Mapping dynamic lipid biochemistry with high spatial and molecular detail

具有高空间和分子细节的动态脂质生物化学图谱

• 批准号: FT190100082
• 负责人: A/Prof Shane Ellis
• 金额: $ 52.05万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-28 至 2024-05-10
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT190100082
• 关键词: Mapping; dynamic; lipid; biochemistry; spatial

Lipids are a complex and underappreciated family of molecules playing important roles in all of our tissues and cells. Yet, our fundamental knowledge of lipids is limited by current technology. This project aims to develop an innovative mass spectrometry imaging platform allowing lipid biochemistry to be visualised at a level of detail not before possible. This will push boundaries in molecular imaging technology and is expected to provide new fundamental knowledge about the structure, function and distributions of lipids in tissues and cells. Significant benefits should include providing new tools to unravel the functions and modifications of lipids in biology, that can be extended to many other research and industrial applications.

类脂是一个复杂的、被忽视的分子家族，在我们所有的组织和细胞中都扮演着重要的角色。然而，我们对脂类的基础知识受到当前技术的限制。该项目旨在开发一种创新的质谱学成像平台，使脂质生物化学能够在不可能的情况下以详细的水平可视化。这将推动分子成像技术的发展，并有望提供有关组织和细胞中脂质的结构、功能和分布的新的基础知识。显著的好处应该包括提供新的工具来解开生物学中脂质的功能和修饰，这些工具可以扩展到许多其他研究和工业应用。