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KINASES & EARLY RESPONSE GENES IN OROFACIAL DEVELOPMENT

KINASES & EARLY RESPONSE GENES IN OROFACIAL DEVELOPMENT
激酶
批准号：
2128794
负责人：
M. Michele Pisano
金额：
$6.87万
依托单位：
THOMAS JEFFERSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1993
资助国家：
美国
项目状态：
已结题
起止时间：
1993-06-01 至 1998-05-31
来源：
https://reporter.nih.gov/project-details/2128794
关键词：
antisense nucleic acid biological signal transduction cell growth regulation developmental genetics embryo /fetus drug adverse effect embryo /fetus tissue /cell culture enzyme activity ethanol gene expression histogenesis hormone regulation /control mechanism in situ hybridization isozymes laboratory mouse mammalian embryology mesenchyme messenger RNA mucopolysaccharides northern blottings oncogenes oncoproteins palate protein kinase C regulatory gene western blottings

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中文摘要
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英文摘要
The extensive alterations in tissue morphology, cellular biochemistry and regulation of gene expression that culminate in the genesis of the midface result from the interaction of multiple hormone- and growth factor-activated signaling pathways. Little attention has been focused on characterization of these pathways and the nuclear events responsible for transducing short-term cellular signals into long-term phenotypic alterations associated with normal orofacial development. This application investigates 1) the role of the signal transducer protein kinase C in mediating the effects of various palatal hormones and growth factors and 2) the role of 'early response' nuclear oncogene families in protein kinase-mediated signal transduction during growth and differentiation of the mammalian secondary palate.
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