KINASES & EARLY RESPONSE GENES IN OROFACIAL DEVELOPMENT

组织形态、细胞生化和组织化学的广泛变化 对基因表达的调节，最终导致脑白质瘤的发生 面部中部是多种激素和生长相互作用的结果 因子激活的信号通路。几乎没有人关注过 关于这些途径的特征和负有责任的核事件 用于将短期细胞信号转换为长期表型 与正常的口腔面部发育相关的改变。这 应用研究1)信号转导蛋白的作用 激酶C在调节各种腭部激素和生长发育中的作用 因素和2)‘早期反应’核癌基因家族在 蛋白激酶介导的生长和发育过程中的信号转导 哺乳动物次级上颚的分化。

The extensive alterations in tissue morphology, cellular biochemistry and regulation of gene expression that culminate in the genesis of the midface result from the interaction of multiple hormone- and growth factor-activated signaling pathways. Little attention has been focused on characterization of these pathways and the nuclear events responsible for transducing short-term cellular signals into long-term phenotypic alterations associated with normal orofacial development. This application investigates 1) the role of the signal transducer protein kinase C in mediating the effects of various palatal hormones and growth factors and 2) the role of 'early response' nuclear oncogene families in protein kinase-mediated signal transduction during growth and differentiation of the mammalian secondary palate.