OUTREACH AGENDA

北卡罗来纳州已经有了大量的女性和 被检测出感染艾滋病毒的儿童。艾滋病毒/艾滋病的几个特征 流行病预测艾滋病毒在妇女和妇女中的问题迅速增加 儿童：例如，妇女和儿童中报告的艾滋病病例百分比 少数民族高于全国平均水平，而且还在增长，而且 与静脉吸毒或异性恋有关的病例比例 传播率也高得不成比例。此外，#年的流行病学数据 我们的州表明，大约四分之一的艾滋病原因可能是 与青春期采取的危险行为有关。 目前ACTG的数据表明，我们的儿科部门是最重要的之一 青少年参加ACTG试验的人数；而且在#年的前四分之一 成人Actus的儿科组成部分，在总招生人数中 儿童/青少年参加ACTG试验。临床关注的三个领域有 演变：(A)向转介的艾滋病毒感染者提供全面服务 婴儿及其母亲；(2)为许多艾滋病毒感染者提供最佳护理 全国血友病综合防治中心的血友病患者 最大的；和(3)建立全州青少年外展计划， 向以下人员提供艾滋病毒教育、预防和医疗转介服务 在我们州，艾滋病毒高危青少年。我们儿科医生的主要目标是 组件是提供协调、最先进的、全面的 对这些患者群体的临床护理，与他们的 参加ACTG研究。正在进行的临床和基础研究工作 在此进行了描述。要求为临床和辅助服务提供支持 与ACTG活动相关的利用的服务。

North Carolina has already has already had substantial numbers of women and children detected with HIV disease. Several features of the HIV/AIDS epidemic predict a rapidly increasing problem with HIV disease in women and children: e.g., the percentages of reported AIDS cases in women and minorities are higher than the national averages and are growing, and the proportions of cases associated with IV drug use or heterosexual transmission are also disproportionately high. Also, epidemiologic data in our state suggest that about one-fourth of our AIDS causes may be associated with risk behaviors adopted during adolescence. Current ACTG data indicate that our pediatric component is one of the top enrollers of adolescents in ACTG trials; and it is in the top quarter of pediatric components of adult ACTUs, in total enrollment of children/adolescents into ACTG trials. Three areas of clinical focus have evolved: (a) provision of comprehensive services to referred HIV-exposed infants and their mothers; (2) optimal care for the many HIV-infected hemophiliacs in our Comprehensive Hemophilia Center, one of the nation's largest; and (3) establishment of a statewide adolescent outreach program, to provide HIV educational, preventive, and medical-referral services to HIV at-risk adolescents in our state. The primary goal of our pediatric component is provision of coordinated, state-of-the-art, comprehensive clinical care to these patient populations, in conjunction with their enrollment into ACTG studies. Ongoing clinical and basic research efforts are described herein. Support is requested for the clinical and ancillary services utilized in associated with ACTG activities.