OUTREACH AGENDA

外展议程

• 批准号: 5205117
• 负责人: CHARLES VAN DER HORST
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5205117
• 关键词: AIDS; AIDS therapy; African American; HIV infections; Hispanic Americans; Native Americans; clinical research; clinical trial phase I; cooperative study; female; human subject; human therapy evaluation; medical outreach /case finding; racial /ethnic difference; women's health

North Carolina has already has already had substantial numbers of women and children detected with HIV disease. Several features of the HIV/AIDS epidemic predict a rapidly increasing problem with HIV disease in women and children: e.g., the percentages of reported AIDS cases in women and minorities are higher than the national averages and are growing, and the proportions of cases associated with IV drug use or heterosexual transmission are also disproportionately high. Also, epidemiologic data in our state suggest that about one-fourth of our AIDS causes may be associated with risk behaviors adopted during adolescence. Current ACTG data indicate that our pediatric component is one of the top enrollers of adolescents in ACTG trials; and it is in the top quarter of pediatric components of adult ACTUs, in total enrollment of children/adolescents into ACTG trials. Three areas of clinical focus have evolved: (a) provision of comprehensive services to referred HIV-exposed infants and their mothers; (2) optimal care for the many HIV-infected hemophiliacs in our Comprehensive Hemophilia Center, one of the nation's largest; and (3) establishment of a statewide adolescent outreach program, to provide HIV educational, preventive, and medical-referral services to HIV at-risk adolescents in our state. The primary goal of our pediatric component is provision of coordinated, state-of-the-art, comprehensive clinical care to these patient populations, in conjunction with their enrollment into ACTG studies. Ongoing clinical and basic research efforts are described herein. Support is requested for the clinical and ancillary services utilized in associated with ACTG activities.

北卡罗来纳州已经有大量的妇女， 发现艾滋病的儿童。 艾滋病毒/艾滋病的几个特点 这一流行病预示着妇女艾滋病毒感染问题将迅速增加， 儿童：例如，报告的妇女艾滋病病例的百分比， 少数民族高于全国平均水平，而且还在增长， 与静脉吸毒或异性恋有关的病例比例 传播也不成比例地高。 此外， 我们的国家表明，大约四分之一的艾滋病原因可能是 与青少年时期的危险行为有关。 目前的ACTG数据表明，我们的儿科部分是最好的之一， 在ACTG试验中招募青少年;它是在前四分之一， 成人ACTU的儿科部分，在总入组人数中， 儿童/青少年参与ACTG试验。 临床重点的三个领域 （a）向转诊的艾滋病毒感染者提供全面服务 婴儿及其母亲;（2）为许多艾滋病毒感染者提供最佳护理 血友病患者在我们的综合血友病中心，国家的一个 最大的;和（3）建立一个全州范围的青少年外展计划， 提供艾滋病毒教育、预防和医疗转介服务， 艾滋病高危青少年在我们国家。 我们儿科的主要目标是 组成部分是提供协调的、最先进的、全面的 对这些患者群体的临床护理， 入组ACTG研究。 正在进行的临床和基础研究工作 在此描述。 要求为临床和辅助 与ACTG活动相关的服务。