Basic and applied study on AIDS-therapy using hybrid liposomes

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We have produced hybrid liposomes (HL) which can be prepared by sonication of vesicular and micellar molecules in a buffer solution. We have investigated the anti-AIDS effects of HL and following results are obtained. (1)Remarkably high therapeutic effects were obtained in the mouse models of adult T-cell leukemia/lymphoma (ATLL) after the treatment with HL on the basis of relative organ weight and histological analysis using hematoxylin-eosin (HE) and immunohistochemical staining of CD4 and CD25. Prolonged survival was obtained in the mouse models of ATLL after the treatment with HL. (2)The anti-HIV-1 activity of cepharanthine (CEP), a natural product derived from Stephania cepharantha Hayata, was evaluated. CEP stabilized plasma membrane fluidity and inhibited HIV-1 envelope-dependent cell-to-cell fusion of HIV-1-infected cells as well as cell-free infection. These findings suggest that HL and CEP should be a new type of nanomedicinal anti-AIDS drug that targets cell-membranes.