SYNTHESIS OF RADIOSENSITIZING AGENTS

放射增敏剂的合成

• 批准号: 3607998
• 负责人: WILLIAM R WILSON
• 金额: $ 15万
• 依托单位: UNIVERSITY OF AUCKLAND
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 1993-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3607998
• 关键词: chemical synthesis; drug interactions; drug quality /standard; drug screening /evaluation; laboratory mouse; neoplasm /cancer radiation therapy; radiopharmacology; radiosensitizer

The objective of this project is to develop the leads which result from the contract effort (N01CM67868) concerned with the screening of compounds for radiosensitizing activity. Analogs of the lead compounds will be synthesized and tested in vitro. The analogs will be developed using the knowledge of the relationship between molecular structure and radiosensitizing effectiveness which has accumulated from past and current studies. New and/or novel radiosensitizers for introduction into the clinic are expected from the proposed project.

该项目的目标是开发来自以下方面的线索 与化合物筛选相关的合同工作 (N01CM67868) 用于放射增敏活性。 先导化合物的类似物将是 合成并在体外进行测试。 类似物将使用 分子结构与分子结构之间的关系的知识 过去和现在积累的放射增敏效果 研究。 引入新的和/或新颖的放射增敏剂 拟议项目预计将有诊所。