SYNTHESIS OF RADIOSENSITIZING AGENTS

放射增敏剂的合成

• 批准号: 3607995
• 负责人: WILLIAM R WILSON
• 金额: $ 20.67万
• 依托单位: UNIVERSITY OF AUCKLAND
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 1993-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3607995
• 关键词: chemical synthesis; drug quality /standard; drug screening /evaluation; laboratory mouse; neoplasm /cancer radiation therapy; radiopharmacology; radiosensitizer

The objective of this project is to develop the leads which result from the contract effort (N01CM67868) concerned with the screening of compounds for radiosensitizing activity. Analogs of the lead compounds will be synthesized and tested in vitro. The analogs will be developed using the knowledge of the relationship between molecular structure and radiosensitizing effectiveness which has accumulated from past and current studies. New and/or novel radiosensitizers for introduction into the clinic are expected from the proposed project.

该项目的目标是开发导致 合同工作（N 01 CM 67868）涉及化合物筛选 放射增敏活性。 先导化合物的类似物将是 合成并在体外测试。 类似物将使用 分子结构与 从过去和现在积累的放射增敏效果 问题研究 新的和/或新颖的放射增敏剂， 诊所预计从拟议的项目。