PATHOLOGY MONITORING AGED HYBRID RAT COLONY

老年杂交大鼠群体的病理学监测

• 批准号: 3590928
• 负责人: BENNETT J COHEN
• 金额: $ 2.76万
• 依托单位: LYLE VETERINARY LABORATORIES
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-03-31 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3590928
• 关键词: animal care; animal colony; animal old age; histopathology; laboratory rat; pathology; postmortem; veterinary medicine

The purpose of this project is to provide an independent surveillance of the health status of rats maintained in contractor facilities for the nine-year hybrid rat colony. One hundred rats per year selected by the Project officer, are to be shipped from the NIA colony to an independent laboratory for health and pathology evaluation. The Project Officer will select animals from the inventory maintained in the NIA Resource Development Office which effectively samples the range of ages and holding rooms that characterize the colony. The evaluation to be performed will include: -Gross Pathology: observation of organs and tissues for gross pathological lesions. -Histopathology: lung, liver, kidney, spleen, brain, and abnormal tissue from gross pathology. -Microbiology: mycoplasma, salmonella, pseudomonas, any abnormal discharges, exudates or inflammatory process. -Parasitology: endoparasites, ectoparasites. -Serology: rat viruses. -Clinical Chemistries: sodium, Potassium, serum electrophoresis, total protein, A/G ratio, cholesterol, creatinine, glucose, CBC. Complete postmortem reports on individual animals shall be submitted to the Project Officer no later than three months from the date the animals are submitted for evaluation. This project is not intended to provide a statistically significant sample of the colony population, but rather to provide a resource to the Project Officer to monitor colony contractor performance and to provide an independent assessment of animal health when needed.

该项目的目的是提供一个独立的 监察承办商饲养的老鼠的健康状况 九年混合鼠群的设施。 一百只老鼠 每年由项目官员选择， 将NIA殖民地转移到一个独立的健康实验室， 病理学评价 项目官员将从以下动物中选择动物： NIA资源开发办公室维护的库存 它有效地采样了年龄范围和拘留室， 描述殖民地的特征。 将进行的评价将 包括以下步骤： - 大体病理学：观察器官和组织的大体 病理损伤 - 组织学：肺、肝、肾、脾、脑及异常 组织从大体 病理 - 微生物学：支原体、沙门氏菌、假单胞菌、任何异常 分泌物、渗出物或炎症过程。 - 寄生虫学：体内寄生虫、体外寄生虫。 - 血清学：大鼠病毒。 - 临床化学：钠、钾、血清电泳， 总蛋白A/G比值胆固醇肌酐葡萄糖全血细胞计数 每只动物的完整尸检报告应 提交给项目官员不迟于三个月， 动物提交评估的日期。 这个项目 不打算提供统计学上显著的样本， 殖民地人口，而是提供资源， 项目官员负责监控殖民地承包商的绩效并 在需要时提供独立的动物健康评估。