PATHOLOGY MONITORING AGED HYBRID RAT COLONY

老年杂交大鼠群体的病理学监测

• 批准号: 3590926
• 负责人: BENNETT J COHEN
• 金额: $ 2.5万
• 依托单位: LYLE VETERINARY LABORATORIES
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-03-31 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3590926
• 关键词: animal care; animal colony; animal old age; histopathology; laboratory rat; pathology; postmortem; veterinary medicine

The purpose of this project is to provide an independent surveillance of the health status of rats maintained in contractor facilities for the nine-year hybrid rat colony. One hundred rats per year selected by the Project officer, are to be shipped from the NIA colony to an independent laboratory for health and pathology evaluation. The Project Officer will select animals from the inventory maintained in the NIA Resource Development Office which effectively samples the range of ages and holding rooms that characterize the colony. The evaluation to be performed will include: -Gross Pathology: observation of organs and tissues for gross pathological lesions. -Histopathology: lung, liver, kidney, spleen, brain, and abnormal tissue from gross pathology. -Microbiology: mycoplasma, salmonella, pseudomonas, any abnormal discharges, exudates or inflammatory process. -Parasitology: endoparasites, ectoparasites. -Serology: rat viruses. -Clinical Chemistries: sodium, Potassium, serum electrophoresis, total protein, A/G ratio, cholesterol, creatinine, glucose, CBC. Complete postmortem reports on individual animals shall be submitted to the Project Officer no later than three months from the date the animals are submitted for evaluation. This project is not intended to provide a statistically significant sample of the colony population, but rather to provide a resource to the Project Officer to monitor colony contractor performance and to provide an independent assessment of animal health when needed.

这个项目的目的是提供一个独立的 监测承办商饲养的老鼠的健康状况 为长达九年的杂交鼠聚居地提供设施。一百只老鼠 每一年由项目官员选择，将从 将NIA殖民地转移到一个独立的健康和 病理评估。项目官员将从以下项目中选择动物 在NIA资源开发办公室维护的库存 有效地抽样了年龄和等待室的范围 描述殖民地的特征。要执行的评估将 包括： 大体病理学：对器官和组织进行大体观察 病理性损伤。 -组织病理学：肺、肝、肾、脾、脑和异常 来自大体的组织 病理学。 -微生物学：支原体、沙门氏菌、假单胞菌、任何异常 分泌物、渗出物或炎症过程。 -寄生虫学：内寄生虫、体外寄生虫。 -血清学：老鼠病毒。 -临床化学：钠、钾、血清电泳法、 总蛋白、A/G比值、胆固醇、肌酐、葡萄糖、CBC。 对单个动物的完整尸检报告应为 不迟于三个月后提交给项目干事 动物被提交进行评估的日期。这个项目 并不打算提供具有统计意义的样本 殖民地人口，而是为 项目主任监督殖民地承建商的表现并 在需要时提供独立的动物健康评估。