CLINICAL DEVELOPMENT OF ANTICANCER AGENTS

抗癌药物的临床开发

• 批准号: 3613349
• 负责人: IRWIN H KRAKOFF
• 金额: $ 11.47万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-01 至 1990-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3613349
• 关键词: antineoplastics; bioassay; chemical information system; dosage; drug adverse effect; drug hypersensitivity; drug metabolism; drug quality /standard; human therapy evaluation; mass spectrometry; neoplasm /cancer pharmacology; nuclear magnetic resonance spectroscopy; prognosis

Phase I and Clinical Pharmacokinetic studies on specific investigational new drugs sponsored Division of Cancer Treatment, National Cancer Institute, and Phase II/III studies in patients with disseminated solid tumors and leukemia.

特定研究的I期和临床药代动力学研究 新药赞助国家癌症治疗部 弥漫性固体患者的II/III期研究 肿瘤和白血病。

项目成果

Phase II study of iproplatin in metastatic breast carcinoma.

异丙铂治疗转移性乳腺癌的 II 期研究。

• 发表时间: 1987
• 期刊: Cancer treatment reports
• 作者: Hortobagyi,GN;Frye,D;Holmes,FA;Hug,V;Fraschini,G;Buzdar,AU
• 通讯作者: Buzdar,AU

Phase II trial of carboplatin plus cisplatin in recurrent and advanced squamous cell carcinoma of the head and neck.

卡铂联合顺铂治疗复发性和晚期头颈部鳞状细胞癌的 II 期试验。

• DOI: 10.1200/jco.1991.9.11.1939
• 发表时间: 1991
• 期刊: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
• 作者: Dimery,IW;Brooks,BJ;Winn,R;Martin,T;Shirinian,M;Hong,WK
• 通讯作者: Hong,WK

Paclitaxel in the treatment of metastatic breast cancer: M.D. Anderson Cancer Center experience.

紫杉醇治疗转移性乳腺癌：M.D. 安德森癌症中心的经验。

• 发表时间: 1995
• 期刊: Seminars in oncology
• 影响因子: 4
• 作者: Buzdar,AU;Holmes,FA;Hortobagyi,GN
• 通讯作者: Hortobagyi,GN

Phase II study of intravenous 6-thioguanine in patients with advanced gastric carcinoma.

晚期胃癌患者静脉注射 6-硫鸟嘌呤的 II 期研究。

• DOI: 10.1007/bf00176979
• 发表时间: 1991
• 期刊: Investigational new drugs
• 影响因子: 3.4
• 作者: Ajani,JA;Pazdur,R;Winn,RJ;Abbruzzese,JL;Levin,B;Wiseman,C;Lenado-Lee,MA;Patt,YZ;Krakoff,IH
• 通讯作者: Krakoff,IH

Clinical pharmacology of trimetrexate.

曲美曲沙的临床药理学。

• DOI: 10.1038/clpt.1987.160
• 发表时间: 1987
• 期刊: Clinical pharmacology and therapeutics
• 影响因子: 6.7
• 作者: Ho,DH;Covington,WP;Legha,SS;Newman,RA;Krakoff,IH
• 通讯作者: Krakoff,IH