PREPARATION OF RADIOLABELED MATERIALS

放射性标记材料的制备

• 批准号: 2300760
• 负责人: JOHN A KEPLER
• 金额: $ 50.44万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-06-30 至 1997-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2300760
• 关键词: PREPARATION; RADIOLABELED; MATERIALS

Synthesize, procure test, and distribute radiolabeled materials. Such- radiolabeled materials are use by intramural and extramural investigators for preclinical and clinical pharmacological studies. Assignments for preparation or procurement of radiolabeled materials are made by the Project Officer and include a wide variety of chemicals and radioactive atom with the major emphasis being on the preparation of the desired labeled materials via synthetic procedures using 14C and tritium. Major emphasis will be on the preparation of the desired radiolabeled compounds via synthetic procedures and will involve a wide variety of compounds. Compounds required may include one or more radioactive elements. Methods of synthesis will be available for "cold runs" in many, but not all, instances. Development of new and/or existing synthetic procedures shall be required. Operate a preparation laboratory for the synthesis of radiolabeled materials. Approximately 5 to 10 radiolabeled preparations per year should be anticipated. Provide storage and distribution of radiolabeled materials for approximately 50 compounds. Weight, package and label all shipments, approximately 10 shipments per month should be anticipated.

合成、采购、测试和分发放射性标记材料。 如此- 放射性标记材料由校内和校外研究者使用 用于临床前和临床药理学研究。 作业 放射性标记材料的制备或采购由 项目官员和包括各种化学品和放射性 原子，主要重点是制备所需的 通过使用14 C和氚的合成程序标记材料。 主要重点将是制备所需的放射性标记的 化合物通过合成程序，并将涉及各种各样的 化合物. 所需的化合物可能包括一种或多种放射性物质， 元素 合成方法将可用于许多， 但不是所有实例。 开发新的和/或现有的合成 必须有程序。 操作制备实验室，用于合成放射性标记的 材料. 每年大约5至10份放射性标记制剂应 被期待。 提供放射性标记材料的储存和分发， 大约50种化合物。 所有货物的重量，包装和标签， 预计每月大约有10批货物。