PERIODIC SCREENING FOR OCCULT STOOL BLOOD

这项随机对照试验旨在确定 筛查粪便中的潜血将降低死亡率 结直肠癌。当这项研究在1975年开始时，一群 45,000人，年龄在50岁至80岁之间，居住在 以前没有结直肠癌病史的明尼苏达州是 按年龄、性别和地理区域随机分为三组 州政府。测试小组每年或每隔一年提交血液隐形切片 其他年份；控制组不提交幻灯片。参与者 谁的幻灯片是阳性的在加州大学进行评估 明尼苏达医院使用指定的诊断方案。全 参与者被要求完成一份简短的年度调查问卷 关于他们的健康状况。这项研究由一个 具有统计、流行病学和信息技术专长的咨询小组 胃肠病学。这项研究将继续进行，直到有意义的 在筛查和对照之间观察到死亡率的差异。 组或直到明确不会有显著差异为止 浮出水面。

This randomized controlled trial is designed to determine whether screening for occult blood in the stool will reduce mortality from colorectal cancer. When the study began in 1975, a cohort of 45,000 individuals between 50 and 80 years of age, residing in the state of Minnesota, with no prior history of colorectal cancer was randomized into three groups by age, sex, and geographic region of the state. Test groups submit Hemoccult slides annually or every other year; the control group does not submit slides. Participants whose slides are positive are evaluated at the University of Minnesota Hospitals using the specified diagnostic protocol. All participants are asked to complete a short annual questionnaire concerning their health status. The study is monitored by an advisory group with expertise in statistics, epidemiology and gastroenterology. The study will continue until a significant difference in mortality is observed between screened and control groups or until it is clear that no significant difference will emerge.