PERIODIC SCREENING FOR OCCULT STOOL BLOOD

这项随机对照试验旨在确定 筛查粪便中的潜血可以降低 结肠直肠癌 当这项研究于1975年开始时， 45 000名年龄在50至80岁之间的人， 明尼苏达州，以前没有结直肠癌病史， 按年龄、性别和地理区域随机分为三组， 该州 测试组每年或每隔一年提交一次Hemoccult切片 其他年份;对照组不提交幻灯片。 参与者 其载玻片呈阳性的人在大学进行评估， 明尼苏达州医院使用指定的诊断协议。 所有 参与者被要求填写一份简短的年度问卷 关于他们的健康状况。 该研究由一名 具有统计学、流行病学和 胃肠病学 这项研究将继续下去，直到一个重大的 在筛选和对照之间观察到死亡率的差异 组或直到很明显，没有显着差异， 出现。

This randomized controlled trial is designed to determine whether screening for occult blood in the stool will reduce mortality from colorectal cancer. When the study began in 1975, a cohort of 45,000 individuals between 50 and 80 years of age, residing in the state of Minnesota, with no prior history of colorectal cancer was randomized into three groups by age, sex, and geographic region of the state. Test groups submit Hemoccult slides annually or every other year; the control group does not submit slides. Participants whose slides are positive are evaluated at the University of Minnesota Hospitals using the specified diagnostic protocol. All participants are asked to complete a short annual questionnaire concerning their health status. The study is monitored by an advisory group with expertise in statistics, epidemiology and gastroenterology. The study will continue until a significant difference in mortality is observed between screened and control groups or until it is clear that no significant difference will emerge.