CLINICAL CENTER FOR VIRAL ACTIVATION TRANSFUSION STUDY

病毒激活输血研究临床中心

• 批准号: 2312771
• 负责人: Charles Michael van der Horst
• 金额: $ 15.76万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-12-01 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2312771
• 关键词: CLINICAL; CENTER; VIRAL; ACTIVATION; TRANSFUSION

This study's objective is to determine if transfusion is followed by the activation of HIV-1 and Cytomegalovirus (CMV) in HIV-1 infected persons and thereby adversely affecting prognosis. It also will evaluate the role of donor leukocytes producing this activation by examining the effect of removing leukocytes by filtration or abolishing their ability to proliferate by gamma irradiation. Finally, the study will examine the persistence of donor lymphocytes after transfusion. The study consists of 11 clinical sites, a central laboratory, and a medical coordinating center.

这项研究的目的是确定输血后是否有 HIV-1感染者HIV-1和巨细胞病毒(CMV)的激活 从而对预后产生不利影响。它还将评估这一角色 产生这种激活的供者白细胞通过检查 通过过滤或取消白细胞的能力来去除白细胞 通过伽马射线扩散。最后，这项研究将审查 供者淋巴细胞在输血后的持久性。 这项研究由11个临床站点、一个中心实验室和一个 医疗协调中心。