SPERM MORPHOLOGY AND VAGINAL CYTOLOGY EVALUATION

精子形态学和阴道细胞学评估

• 批准号: 2309303
• 负责人: DUSNYANT K GULATI
• 金额: --
• 依托单位: ENVIRONMENTAL HEALTH RESEARCH & TESTING
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-05-01 至 1994-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2309303
• 关键词: SPERM; MORPHOLOGY; VAGINAL; CYTOLOGY; EVALUATION

This project has two primary objectives: 1) to collect data from rodent male and female reproductive systems at the end of 90 day studies, to determine if there are adverse effects of treatment on these systems. These data are used to identify candidates for further reproductive toxicity testing. 2) to collect videographic data on sperm motility from animals treated under the Reproductive Assessment by Continuous Breeding contract. The purpose of this is to identify meaningful relationships between changes in sperm motility patterns, and fertility. We don't know these relationships now, despite widespread use of these machines. This will help the field focus in on the endpoints with the greatest relationship to fertility, to allow us to spend our decreasing resources more efficiently in the future.

该项目有两个主要目标： 1)收集啮齿动物雄性和雌性生殖系统的数据， 90天研究结束，以确定是否有不良影响 在这些系统上的治疗。 这些数据用于识别候选人， 进一步的生殖毒性试验。 2)收集处理动物精子活力的视频数据 根据连续育种合同进行的生殖评估。 的 其目的是确定变化之间的有意义的关系， 精子活动模式和生育能力 我们不知道这些关系 现在，尽管这些机器的广泛使用。 这将有助于外地 重点关注与生育率关系最大的终点， 使我们能够在未来更有效地利用日益减少的资源。