PRECHRONIC INHALATION STUDY OF VANADIUM PENTOXIDE

五氧化二钒的慢性吸入研究

• 批准号: 2311579
• 负责人: CATHERINE ARANYI
• 金额: $ 16.68万
• 依托单位: IIT RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-06-29 至 1991-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2311579
• 关键词: PRECHRONIC; INHALATION; STUDY; VANADIUM; PENTOXIDE

Vanadium pentoxide is a product of the processing of uranium and iron ores. Human exposure to during the handling and processing of these ores. The objectives of the planned prechronic (14-day & 13-week) inhalation studies is to determine the toxic effects of vanadium pentoxide aerosols in rats and mice. other objectives include the identification of target organs for the toxic effects of the chemical, determination of the no-effect-level, and determining differences in sensitivity between sexes and species. Data to be collected include morphologic and clinical pathology, sperm morphology and vaginal cytology, pulmonary and cardiovascular function indices, neurotoxic effects as well as renal function indices.

五氧化二钒是铀和铁加工的产物 石. 人类在处理和加工这些 石. 计划的慢性前（14天和13周）吸入的目的 研究的目的是确定五氧化二钒气溶胶的毒性作用 在大鼠和小鼠中。其他目标包括确定目标 器官对化学品毒性作用的敏感性测定 无效应水平，并确定性别之间的敏感性差异 和物种。 收集的数据包括形态学和临床 病理学、精子形态学和阴道细胞学、肺和 心血管功能指数、神经毒性作用以及肾毒性 功能指标