PRECHRONIC INHALATION STUDY OF VANADIUM PENTOXIDE

五氧化二钒的慢性吸入研究

• 批准号: 2311582
• 负责人: CATHERINE ARANYI
• 金额: $ 11.47万
• 依托单位: IIT RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-06-29 至 1991-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2311582
• 关键词: PRECHRONIC; INHALATION; STUDY; VANADIUM; PENTOXIDE

Vanadium pentoxide is a product of the processing of uranium and iron ores. Human exposure to during the handling and processing of these ores. The objectives of the planned prechronic (14-day & 13-week) inhalation studies is to determine the toxic effects of vanadium pentoxide aerosols in rats and mice. other objectives include the identification of target organs for the toxic effects of the chemical, determination of the no-effect-level, and determining differences in sensitivity between sexes and species. Data to be collected include morphologic and clinical pathology, sperm morphology and vaginal cytology, pulmonary and cardiovascular function indices, neurotoxic effects as well as renal function indices.

五氧化二钒是铀和铁加工的产物。 矿石。人类在处理和处理这些东西的过程中接触到的 矿石。 计划的慢性前期(14天和13周)吸入的目标 研究是确定五氧化二钒气雾剂的毒性效应 在大鼠和小鼠身上。其他目标包括确定目标 化学物质毒性作用器官的测定 无效应水平，并确定性别之间的敏感度差异 和物种。收集的数据包括形态和临床 病理，精子形态和阴道细胞学，肺和 心血管功能指数、神经毒性效应以及肾脏 功能指数。