TOXICOLOGY OF AIDS THERAPEUTICS

该合同的目的是进行最多六项毒性研究 在啮齿类动物中持续数月。这些研究应按照以下规定进行 《总工作说明》的程序和要求 系统毒力科和为特定目标制定的研究方案 治疗学。这样的研究应该1)提供艾滋病的筛查 单独或联合对大鼠和/或小鼠进行治疗 一般毒性、生殖/发育毒性和其他系统特有的毒性， 以及2)提供一种机制来研究一般毒性的发展 在接受艾滋病治疗的大鼠和小鼠中，单独或联合使用， 在很长一段时间内。应执行以下任务： 任务Ia：对啮齿动物的生殖/发育一般毒性研究 暴露于单一的治疗剂或多种治疗药物的组合中。 任务Ib：单一治疗药物对啮齿动物的28天毒性研究 或者是治疗学的组合。 任务II：对啮齿动物进行为期13周(90天)的毒性研究 治疗学或治疗学的组合。 任务III：对啮齿动物进行为期6个月的单一毒剂或 一组特工的组合。

The purpose of the Contract is to conduct toxicity studies of up to six months duration in rodents. These studies shall be conducted according to the procedures and requirements of the General Statement of Work for the Systems Toxicity Branch and study protocols developed for specific therapeutics. Such studies shall 1) provide a screen for AIDS therapeutics, administered alone or in combination to rats and/or mice, for general, reproductive/developmental, and other systems-specific toxicities, and 2) provide a mechanism to study the development of general toxicities in rats and mice administered AIDS therapeutics, alone or in combination, over an extended period of time. The following tasks shall be performed: TASK Ia: REPRODUCTIVE/DEVELOPMENTAL GENERAL TOXICITY STUDIES ON RODENTS EXPOSED TO A SINGLE THERAPEUTIC AGENT OR A COMBINATION OF THERAPEUTICS. TASK Ib: 28-DAY TOXICITY STUDIES ON RODENTS EXPOSED TO A SINGLE THERAPEUTIC OR A COMBINATION OF THERAPEUTICS. TASK II: 13-WEEK (90-DAY) TOXICITY STUDIES ON RODENTS EXPOSED TO A SINGLE THERAPEUTIC OR A COMBINATION OF THERAPEUTICS. TASK III: 6-MONTH TOXICITY STUDIES ON RODENTS EXPOSED TO A SINGLE AGENT OR A COMBINATION OF AGENTS.