SUPPORT SERVICES FOR STUDIES OF PERINATAL TRANSMISSION

自1988年以来，国家儿童健康和人类发展研究所 (NICHD)已为一项支持服务合同提供资金，以进行 母婴队列研究与母婴研究 传播研究(WITS)。这些研究的重点是开发一种 对感染艾滋病毒的妇女传播机制的了解 他们对婴儿的感染以及艾滋病毒暴露对这些人的影响 婴儿，包括感染和未感染的儿童。这些研究已经 还检查了这些女性随着时间的推移疾病的进展情况。这个 免疫学、神经学和神经发育的研究进展 引起的问题和严重的细菌和机会性感染 这些研究中的HIV感染对于制定适当的 新的抗逆转录病毒临床试验中的疾病进展措施 艾滋病病毒感染儿童的药物。 母婴队列研究(MIS)已完成ITS 孕妇队列，目前正专注于主要数据分析 在这份新合同下的努力。虽然最初的临床发现是 预计将在明年完成，对儿童的后续工作 以及对过去五年收集的丰富数据的分析 该项目预计还需要大约三到四年的时间 需要数年时间才能完成。妇幼传播研究(WITS) 继续招收感染艾滋病毒的孕妇，并已将其 确定疟疾流行危险因素的主要关注点 感染从母体传播到婴儿的测定 传播的时间(宫内和产中)和 婴幼儿感染的早期诊断方法。有能力 早期准确判断暴露儿感染状况 时间将允许采取早期干预策略来预防 感染婴儿的疾病进展，同时避免潜在的 使未受感染的婴儿接触有毒疗法。标的物合同 将继续提供所需的支持和分析服务 这两项研究。

Since 1988, the National Institute of Child Health and Human Development (NICHD) has provided funding for a support services contract to conduct the Mothers and Infants Cohort Study (MIS) and the Women and Infants Transmission Study (WITS). These studies have focused on developing an understanding of the mechanisms by which women infected with HIV transmit their infection to their infants and the effects of HIV exposure on those infants, both among the infected and uninfected children. The studies have also examined the progression of disease in the women over time. The ascertainment of the immunologic, neurologic and neurodevelopmental problems and serious bacterial and opportunistic infections resulting from HIV infect ion in these studies is critical to developing appropriate measures of disease progression in clinical trials of new anti-retroviral drugs in HIV-infected children. The Mothers and Infants Cohort Study (MIS) has completed enrollment of its cohort of pregnant women and is currently focusing on major data analysis efforts under this new contract. While the initial clinical findings are expected to be completed in the next year, the follow-up of the children and the analysis of the wealth of data collected during the past five years of the project is expected to take approximately three to four more years to complete. The Women and Infants Transmission Study (WITS) continues to enroll HIV-infected pregnant women and has shifted its primary focus from determining the epidemiologic risk factors for transmission of infection from mother to infant to the determination of the timing of transmission (intrauterine versus intrapartum) and to methods of early diagnosis of infection in the infant. The ability to accurately determine the infection status of exposed infants at an earlier time will allow for pursuit of early intervention strategies to prevent progression of disease in infected infants, while avoiding potential exposure of uninfected infants to toxic therapies. The subject contract will continue to provide the support and analytical services required for the two studies.