PREPARATION OF RADIOLABELED SPHINGOLIPIDS

放射性标记鞘脂的制备

• 批准号: 3668584
• 负责人: Alexander L Weis
• 金额: $ 8.92万
• 依托单位: LIPITEK INTERNATIONAL, INC.
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-03-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3668584
• 关键词: chemical synthesis; radiotracer; sphingolipids

The contractor shall prepare and deliver, over a three year period, a source of radiolabeled sphingolipids to the intramural laboratories of the NINDS, which are needed to support basic and clinical investigations of Gaucher's disease, Niemann-Pick disease, and Fabry's disease. Specifically, these radiolabeled sphingolipids are required for: 1) monitoring the catalytic activity and enzymes being developed for replacement therapy in patients with the above mentioned disorders; and 2) elucidation of metabolic errors in patients with these diseases.

承包商应在三年内编制并交付 放射性标记鞘脂的来源， NINDS，用于支持基础和临床研究 高雪氏病、尼曼-匹克病和法布里病。 具体而言，需要这些放射性标记的鞘脂：1） 监测催化活性和正在开发的酶， 对患有上述疾病的患者进行替代治疗;以及 2)阐明这些疾病患者的代谢错误。