ELECTROPHYSIOLOGY OF COGNITIVE DECLINE IN AGING AND DEMENTIA

本项目的总体目标是纵向与横向相结合 识别认知功能减退标志物的分段方法学 通常是衰老和精神错乱的个体。除了纵向的 事件相关电位的时间和空间方面的变化数据 (事件相关电位)，特定的实验将评估认知操作 老年人和痴呆症高危人群的脆弱性：语义 激活、记忆任务编码的精细化和运动减慢。 事件相关电位(ERPs)将被记录在头皮、时间 锁定在听觉和视觉刺激上。预计事件相关电位波形将 随实验条件、年龄和认知能力的不同而变化 减值，从而提供了时间和效率的衡量 三组老年人的认知加工：正常、高危 痴呆症，精神错乱。详细的头皮地形分析，利用 无参照物经颅测量的拉普拉斯方法 目前的流量，将提供与年龄相关的变化的指示 这些事件相关电位成分在颅内的不同产生。

The overall goal of this project is to combine longitudinal and cross sectional methodologies to identify markers of cognitive decline in normally aging and dementing individuals. In addition to the longitudinal data on changes in temporal and spatial aspects of event-related potentials (ERPs), specific experiments will assess cognitive operations that are vulnerable in the elderly and those at risk for dementia: semantic activation, elaboration at encoding on memory tasks, and motor slowing. Event-related potentials (ERPs) will be recorded from the scalp, time locked to auditory and visual stimuli. The ERP waveform is expected to vary as a function of experimental condition, age, and cognitive impairment, thus providing measures of the timing and efficiency of cognitive processing in three groups of the aged: normal, high risk for dementia, and demented. A detailed scalp topographic analysis, utilizing the Laplacian method for reference free measurements of transcranial current flow, will provide an indication of age-related change in the differential intracranial generation of these ERP components.