CRYO-ROP PARTICIPATING CENTER--PHASE III

CRYO-ROP 参与中心--第三期

• 批准号: 2545852
• 负责人: RAND SPENCER
• 金额: $ 1.02万
• 依托单位: TEXAS RETINA ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1998-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2545852
• 关键词: child (0-11); color visions; cooperative study; cryotherapy; disease /disorder proneness /risk; eye disorder diagnosis; human subject; human therapy evaluation; longitudinal human study; low birth weight infant human; pediatrics; perimetry; premature infant human; retinopathy of prematurity; vision disorders; visual fields; visual perception

DESCRIPTION (Investigator's Abstract) "The purpose of the proposed study is to examine the long-term structural and functional effects of cryotherapy as a treatment for severe retinopathy of prematurity (ROP). In the initial phase of the study, eyes with 5 contiguous or 8 total clock hours of stage 3 plus ROP, in 291 infants with birth weights less than 1251 grams, were randomized to receive cryotherapy or not cryotherapy. Follow-up to age 12 months indicated that cryotherapy reduced the incidence of unfavorable structural outcome by 45.8 percent and the incidence of unfavorable visual acuity outcome by 37.8 percent. Based on the preliminary data, follow-up to age 42 months during Phase II of the study indicated that cryotherapy reduced the incidence of unfavorable structural outcome by 39.1 percent. As for vision, cryotherapy reduced the incidence of unfavorable resolution acuity outcome by 21.4 percent, and by 19.7 percent when based on measurement of recognition acuity. The present study proposes to follow patients in the randomized group and a relatively small subgroup (67) of potentially high risk patients from the Natural History Stud through age 10 years, to determine whether the reduction in the benefit of cryotherapy seen between ages 12 and 42 months continues into mid-childhood. Evaluation of the effects of cryotherapy will be based on examination findings in the posterior pole of the eye and on assessment of visual acuity, as in Phase II. In addition, a more complete evaluation of visual acuity will be conducted at age 9 years, through assessment of monocular contrast sensitivity, monocular contrast sensitivity, monocular color vision, and stereopsis, and at age 10 years, through measurement of the extent of the visual field by Goldmann perimetry."

描述（研究者摘要）

项目成果

Evidence that donor cells are present in the thymus of recipients undergoing a P----F1 graft-versus-host reaction exacerbated by concurrent murine cytomegalovirus infection.

有证据表明，供体细胞存在于接受者的胸腺中，该反应正在经历 P----F1 移植物抗宿主反应，并因并发的鼠巨细胞病毒感染而加剧。

• 发表时间: 1992
• 期刊: Transplantation
• 影响因子: 6.2
• 作者: Cray,C;Levy,RB
• 通讯作者: Levy,RB

Studies on the induction of anterior chamber-associated immune deviation (ACAID). II. Eye-derived cells participate in generating blood-borne signals that induce ACAID.

前房相关免疫偏差（ACAID）诱导的研究。

• 发表时间: 1991
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Wilbanks,GA;Mammolenti,M;Streilein,JW
• 通讯作者: Streilein,JW

Distinctive humoral immune responses following anterior chamber and intravenous administration of soluble antigen. Evidence for active suppression of IgG2-secreting B lymphocytes.

前房和静脉注射可溶性抗原后出现独特的体液免疫反应。

• 发表时间: 1990
• 期刊: Immunology
• 影响因子: 6.4
• 作者: Wilbanks,GA;Streilein,JW
• 通讯作者: Streilein,JW

Simultaneous, bilateral diabetic ophthalmoplegia. Report of two cases and discussion of differential diagnosis.

同时出现双侧糖尿病性眼肌麻痹。

• DOI: 10.1016/s0161-6420(84)34333-0
• 发表时间: 1984
• 期刊: Ophthalmology
• 影响因子: 13.7
• 作者: Sergott,RC;Glaser,JS;Berger,LJ
• 通讯作者: Berger,LJ

5-fluorouracil and glaucoma filtering surgery: I. An animal model.

5-氟尿嘧啶和青光眼滤过手术：I.动物模型。

• DOI: 10.1016/s0161-6420(84)34277-4
• 发表时间: 1984
• 期刊: Ophthalmology
• 影响因子: 13.7
• 作者: Gressel,MG;Parrish2nd,RK;Folberg,R
• 通讯作者: Folberg,R