1997 FASEB SUMMER RESEARCH CONFERENCE ON AMYLOID

该申请要求部分资金支持1997年FASEB 夏季淀粉样蛋白和其他异常淀粉样蛋白研究会议 蛋白质组装过程，将在铜山举行， 1997年7月13日至18日，科罗拉多。 这次会议的主要目的是 汇集了临床医生和细胞生物学家熟悉的生物学， 异常蛋白质沉积与分子生物学家和生物药理学家 他将最终建立一个理解的分子基础 这些现象。 申请人希望本次会议提供 一个论坛，以促进提高对蛋白质沉积的认识， 这一过程不仅与生物学相关， 分子结构和特异性。 重点是 淀粉样疾病的潜在分子基础，蛋白质聚集 （特别是淀粉样蛋白和包涵体形成）和其他 蛋白质-蛋白质相互作用的表现（例如，域交换）， 以及潜在的干预方法。 会议 出席人数只限一百六十人。 特邀演讲人将 从这些领域的领导者中选出，特别是 强调代表性不足的群体。 会议将包括 一个主题演讲提供了淀粉样蛋白的历史，九个正式会议， 口头介绍以及海报展示会和讲习班 会议，其主题将包括蛋白质和β折叠结构， 蛋白质折叠聚集，细菌包涵体，朊病毒 颗粒，主要淀粉样疾病的临床总结，结构 肽类淀粉样蛋白形成的基础， 阿尔茨海默病，物理方法研究不溶性 蛋白质复合物和体内与淀粉样蛋白相关的因子。 的 FASEB夏季研究会议的形式是理想的 鼓励在发展研究领域的相互促进; 会议规模有限，会议日程集中， 所有的气氛都鼓励参与者之间的互动。

This application requests partial funding to support the 1997 FASEB Summer Research Conference on Amyloid and Other Abnormal Protein Assembly Processes, to be held at Copper Mountain, Colorado, July 13-18, 1997. The main objective of this meeting is to bring together clinicians and cell biologists familiar with the biology of abnormal protein deposition with molecular biologists and biophysicists who will ultimately establish an understanding of the molecular basis of these phenomena. The applicants intend this conference to provide a forum to promote increased awareness of protein deposition as a process that is not only biologically relevant but also exhibits significant molecular structure and specificity. The focus is on the underlying molecular basis of amyloid diseases, protein aggregation (especially amyloid and inclusion body formation) and other manifestations of prtein-protein interactions (e.g., domain swapping), as well as potential methods of intervention. The conference attendance will be resricted to 160 participants. Invited speakers will be chosen from among the leaders in these fields, with particular emphasis on under-represented groups. The conference will consist of a keynote address providing a history of amyloid, nine formal sessions of oral presentations, as well as poster sessions and a workshop session, whose topics will include protein and beta sheet structure, protein aggregation during folding, bacterial includsion bodies, prion particles, clinical summaries of major amyloid diseases, structural basis of amyloid formation by peptides, the amyloid pathway in Alzheimer's disease, physical methods for the study of insoluble protein complexes, and factors associated with amyloid in vivo. The format of the FASEB Summer Research Conferences is ideal for stimulating cross-fertilization in developing areas of research; the limited size of the conference, focused meeting schedule and isolated atmosphere all encourage interactions among the participants.