CONFERENCE ON PROCESSING OF PEPTIDE HORMONES

这次会议的目的是把研究多肽的科学家聚集在一起。 处理酶和胞内分选机制从生化， 从细胞生物学、发育和遗传学的角度来看， 对这些过程的全面理解将会出现。的范围 这次会议将讨论的主题将是一次巨大的学习 将使初级科学家(学生和后科学家)受益的经验 博士)以及公认的科学家。另外，这次会议将举行 与高度相关的Keystone会议和联合形式同时举行 将产生大量的多学科互动。 许多具有重要生物学意义的蛋白质和多肽被合成为 需要蛋白水解性切割的非活性前体 生物活性的。最近的进展导致了对 负责这些激活步骤的几种酶及其机制 通过这些蛋白质被定位到正确的细胞器中 蛋白质的降解过程发生了。此外，一些具有遗传缺陷的 最近在人类、小鼠和 在低等生物体中；这些缺陷会引起各种生理变化 包括肥胖、不孕不育和糖尿病。加工的阻滞剂 酶正在被开发用于广泛的应用，包括 抗病毒药物、抗高血压药物、止痛药和化疗药物。 为了了解蛋白质和多肽加工的复杂系统， 需要广泛的方法。这次会议的一个重要方面 将把来自不同领域的科学家聚集在一起，他们是 解决相同的问题，但使用不同的技术。同学们， 博士后和老牌科学家将受益于接触 不同的系统，以及协作的潜力；通过 合作，研究可以更有效地进行，因此NIH 这次会议的资金是有充分理由的。

The aim of this meeting is to bring together scientists studying peptide processing enzymes and intracellular sorting mechanisms from biochemical, cell biological, developmental, and genetic perspectives so that a more comprehensive understanding of the processes will emerge. The range of topics to be covered at this meeting will be a tremendous learning experience that will benefit both junior scientists (students and post- docs) as well as established scientists. Also, this meeting will be held concurrently with a highly related Keystone meeting, and the joint format will produce a large number of multidisciplinary interactions. Many biologically important proteins and peptides are synthesized as inactive precursors that require proteolytic cleavage to become biologically active. Recent advances have led to the identification of several enzymes responsible for these activation steps, and the mechanism by which proteins are targeted to the correct cellular organelle where proteolytic processing occurs. In addition, genetic defects with some of the processing enzymes have recently been identified in humans, mice, and in lower organisms; these defects cause a variety of physiological changes including obesity, sterility, and diabetes. Inhibitors of the processing enzymes are being developed for a wide range of applications including antiviral agents, antihypertensives, analgesics, and chemotherapeutics. To understand the complex systems of protein and peptide processing, a wide array of approaches are needed. One important aspect of this meeting will be to bring together scientists from different fields, who are working on the same problems, but using different techniques. Students, post-docs, and established scientists will benefit from the exposure to different systems, and the potential for collaborations; through collaborations, research can be conducted more efficiently, and so NIH funding is well justified for the meeting.