CONFERENCE ON PROCESSING OF PEPTIDE HORMONES

肽激素加工会议

• 批准号: 2017815
• 负责人: LLOYD D FRICKER
• 金额: $ 0.5万
• 依托单位: KEYSTONE CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-03 至 1998-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2017815
• 关键词: health science research; meeting /conference /symposium; peptide hormone; peptide hormone biosynthesis; travel

The aim of this meeting is to bring together scientists studying peptide processing enzymes and intracellular sorting mechanisms from biochemical, cell biological, developmental, and genetic perspectives so that a more comprehensive understanding of the processes will emerge. The range of topics to be covered at this meeting will be a tremendous learning experience that will benefit both junior scientists (students and post- docs) as well as established scientists. Also, this meeting will be held concurrently with a highly related Keystone meeting, and the joint format will produce a large number of multidisciplinary interactions. Many biologically important proteins and peptides are synthesized as inactive precursors that require proteolytic cleavage to become biologically active. Recent advances have led to the identification of several enzymes responsible for these activation steps, and the mechanism by which proteins are targeted to the correct cellular organelle where proteolytic processing occurs. In addition, genetic defects with some of the processing enzymes have recently been identified in humans, mice, and in lower organisms; these defects cause a variety of physiological changes including obesity, sterility, and diabetes. Inhibitors of the processing enzymes are being developed for a wide range of applications including antiviral agents, antihypertensives, analgesics, and chemotherapeutics. To understand the complex systems of protein and peptide processing, a wide array of approaches are needed. One important aspect of this meeting will be to bring together scientists from different fields, who are working on the same problems, but using different techniques. Students, post-docs, and established scientists will benefit from the exposure to different systems, and the potential for collaborations; through collaborations, research can be conducted more efficiently, and so NIH funding is well justified for the meeting.

这次会议的目的是聚集研究肽的科学家 生物化学中的加工酶和细胞内分选机制， 细胞生物学、发育和遗传的观点，以便更多 将会出现对这些过程的全面理解。 范围为 这次会议讨论的主题将是一次巨大的学习 经验将使初级科学家（学生和博士后）受益 文档）以及知名科学家。 另外，本次会议将召开 同时举办高度相关的 Keystone 会议，以及联合形式 将产生大量的多学科互动。 许多生物学上重要的蛋白质和肽被合成为 无活性的前体，需要蛋白水解裂解才能成为 具有生物活性。 最近的进展已导致识别 负责这些激活步骤的几种酶及其机制 通过这种方法，蛋白质可以靶向正确的细胞器，其中 发生蛋白水解加工。 此外，某些基因缺陷 最近在人类、小鼠和小鼠体内发现了加工酶 在低等生物中；这些缺陷会引起各种生理变化 包括肥胖、不育和糖尿病。 加工抑制剂 酶正在被开发用于广泛的应用，包括 抗病毒药、抗高血压药、镇痛药和化疗药。 为了了解蛋白质和肽加工的复杂系统， 需要采取多种方法。 这次会议的一个重要方面 将汇集来自不同领域的科学家 解决相同的问题，但使用不同的技术。 学生， 博士后和知名科学家将受益于接触 不同的系统以及合作的潜力；通过 合作，研究可以更有效地进行，因此 NIH 为这次会议提供资金是完全合理的。