Engineering a physiologically-relevant blood vessel in vitro

体外设计生理相关血管

• 批准号: LP180100540
• 负责人: Prof Steven Wise
• 金额: $ 35.26万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP180100540
• 关键词: Engineering; physiologically; relevant; blood; vessel

The project will develop an in vitro blood vessel model which will mimic arterial conditions by incorporating vascular cells and silk conduits as scaffolds, for the first time. This approach will overcome the limitations of simplistic 2D cell cultures, the long maturation times of fully tissue-engineered vessels, and resource intensive animal models. The innovative bioengineered construct proposed builds on the CI’s significant advances in materials and surface engineering and the Partner Organisation’s (Codex Research) new bioreactor platform. It will offer a solution for modelling of native vessel processes in vitro that would be more appropriate for pre-clinical drug and device development, and in the long-term, tissue replacement.

该项目将开发一种体外血管模型，该模型将首次通过将血管细胞和丝导管作为支架来模拟动脉状况。这种方法将克服简单的2D细胞培养、完全组织工程化血管的长成熟时间和资源密集型动物模型的局限性。提出的创新生物工程结构建立在CI在材料和表面工程方面的重大进展以及合作伙伴组织（Codex Research）的新生物反应器平台的基础上。它将为体外天然血管过程建模提供一种解决方案，更适合临床前药物和器械开发，以及长期组织替代。