Engineering new tools to aid structure determination of membrane proteins

设计新工具来帮助确定膜蛋白的结构

• 批准号: LP180100560
• 负责人: Dr David Thal
• 金额: $ 32.62万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-10-09 至 2022-12-12
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP180100560
• 关键词: Engineering; new; tools; aid; structure

This project aims to address the inherent instability of G protein-coupled receptors (GPCRs), which are cell-surface proteins that are a major drug targets. The instability of GPCRs has resulted in a lack of atomic-level structural information that has hindered structure-based drug discovery efforts. This project expects to develop tools to improve GPCR stability and streamline the structure determination process. Project outcomes are intended to lead to significant advances in membrane protein structure determination and will have a substantial impact on future research in the pharmaceutical industry.

该项目旨在解决G蛋白偶联受体（GPCR）的固有不稳定性，GPCR是一种主要的药物靶点细胞表面蛋白。GPCR的不稳定性导致缺乏原子水平的结构信息，这阻碍了基于结构的药物发现工作。该项目旨在开发工具，以提高气相化学还原反应的稳定性并简化结构测定过程。项目成果旨在导致膜蛋白结构测定的重大进展，并将对制药行业的未来研究产生重大影响。