Molecular insight into allosteric modulation of G protein-coupled receptors

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The project aims to understand the molecular mechanisms underlying signal transduction and allosteric modulation of G protein-coupled receptors (GPCRs). Allosteric modulation of proteins is a fundamental process where two distinctly different binding sites are linked through a conformational change. This project will use structural biology, medicinal chemistry and analytical pharmacology to investigate how chemical probes modulate GPCRs at an atomic level, and understand the mechanisms underlying signal transduction. Project outcomes are intended to advance membrane protein crystallography and GPCR biology, and benefit the pharmaceutical industry.