KIDNEY DISEASE/HYPERTENSION IN AFRICAN AMERICANS--DCC
KIDNEY DISEASE/HYPERTENSION IN AFRICAN AMERICANS--DCC
批准号:
2149046
负责人:
Michael Henry Kutner
金额:
$162.48万
依托单位国家:
美国
项目类别:
财政年份:
1994
资助国家:
美国
项目状态:
已结题
起止时间:
1994-08-15 至 2001-06-30
关键词:
ACE inhibitors African American antihypertensive agents blood pressure calcium channel blockers cardiovascular disorder chemotherapy chronic renal failure clinical trials cooperative study data collection glomerular filtration rate health science research analysis /evaluation human data human therapy evaluation information systems kidney disorder diagnosis renal hypertension statistics /biometry
中文摘要
非洲裔美国人研究数据协调中心(DCC)
英文摘要
The Data Coordinating Center (DCC) for the African American Study of
Kidney Disease and Hypertension (AASK) Full-Scale Trial will coordinate
the scientific and operational aspects of the Study. This Study will
examine the effectiveness of three stepped-care regimens in lowering blood
pressure and two levels of blood pressure control in African Americans
with hypertensive renal disease in order to slow the loss of kidney
function as measured by glomerular filtration rate.
In the transition months of the Recruitment Phase (Phase I), the DCC will
review the Pilot Study data and protocol in conjunction with the Steering
Committee to finalize the design of the Full-Scale Trial. Systems for data
acquisition (via distributed data entry) and data management (using
Oracle) will be established. A major activity of the DCC will be the
development of procedures for control of the quality of the data. Review
and finalization of the Manual of Operations and data forms will be done.
The randomization schedule for entering patients will be generated.
Central facilities at the Cleveland Clinic will be established for the
measurement of renal function and biochemistry along with a Drug
Distribution Center to coordinate the distribution of antihypertensive
medications. The DCC will provide centralized training of Clinical Center
staff in the areas of entry of study subjects, completion of study forms,
use of the distributed data entry system and testing of renal function.
The DCC will arrange meetings of the Steering Committee and participate in
these meetings and report the proceedings.
The database management system developed in Phase I will be used to assure
accurate and complete collection of study data. A query system will be
used to resolve data discrepancies. A major function of the DCC during the
Recruitment Phase (Phase I) of the study will be to monitor patient
recruitment and compliance as a whole and by Clinical Center. Study
progress will be reported in monthly reports to the Clinical Centers,
newsletters, and presentations at the Steering Committee, and Data and
Safety Monitoring Board meetings. Statistical analyses will be performed
during the course of the study with final analyses completed and reported
during Phase III of the study. The DCC will develop new statistical
methodology as needed to properly analyze the data being collected.
Since the Study is a multi-centered effort including several
organizational components, the DCC will be proactive in performing its
duties so that the goals of the study are met. The DCC will work to foster
a spirit of cooperation which is important in this multi-center study.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Special Scientific Procedures: Statistical Modeling Core
-
批准号:8119604
-
项目类别:
-
资助金额:$4.8万
-
财政年份:2010
-
负责人:Michael Henry Kutner
-
依托单位:
Biostatistical Core Data Management Core
-
批准号:7931300
-
项目类别:
-
资助金额:$20.66万
-
财政年份:2010
-
负责人:Michael Henry Kutner
-
依托单位:
Melatonin Supplementation and the Metabolic Syndrome
-
批准号:8309850
-
项目类别:
-
资助金额:$7.75万
-
财政年份:2009
-
负责人:Michael Henry Kutner
-
依托单位:
Melatonin Supplementation and the Metabolic Syndrome
-
批准号:8094380
-
项目类别:
-
资助金额:$18.99万
-
财政年份:2009
-
负责人:Michael Henry Kutner
-
依托单位:
Melatonin Supplementation and the Metabolic Syndrome
-
批准号:7877913
-
项目类别:
-
资助金额:$19.18万
-
财政年份:2009
-
负责人:Michael Henry Kutner
-
依托单位:
Special Scientific Procedures: Statistical Modeling Core
-
批准号:7892516
-
项目类别:
-
资助金额:$4.73万
-
财政年份:2009
-
负责人:Michael Henry Kutner
-
依托单位:
Biostatistics
-
批准号:7667902
-
项目类别:
-
资助金额:$17.1万
-
财政年份:2008
-
负责人:Michael Henry Kutner
-
依托单位:
Biostatistics and Data Management Core (BDMC)
-
批准号:8342009
-
项目类别:
-
资助金额:$20.36万
-
财政年份:2008
-
负责人:Michael Henry Kutner
-
依托单位:
Biostatistics
-
批准号:7279020
-
项目类别:
-
资助金额:$16.18万
-
财政年份:2007
-
负责人:Michael Henry Kutner
-
依托单位:
KIDNEY DISEASE/HYPERTENSION IN AFRICAN AMERICANS--DCC
-
批准号:2149045
-
项目类别:
-
资助金额:$94.94万
-
财政年份:1994
-
负责人:Michael Henry Kutner
-
依托单位:
KIDNEY DISEASE/HYPERTENSION IN AFRICAN AMERICANS--DCC
-
批准号:2734186
-
项目类别:
-
资助金额:$180.8万
-
财政年份:1994
-
负责人:Michael Henry Kutner
-
依托单位:
KIDNEY DISEASE/HYPERTENSION IN AFRICAN AMERICANS--DCC
-
批准号:2149047
-
项目类别:
-
资助金额:$176.04万
-
财政年份:1994
-
负责人:Michael Henry Kutner
-
依托单位:
KIDNEY DISEASE/HYPERTENSION IN AFRICAN AMERICANS--DCC
-
批准号:2444134
-
项目类别:
-
资助金额:$149.81万
-
财政年份:1994
-
负责人:Michael Henry Kutner
-
依托单位:
Biostatistics
-
批准号:8308424
-
项目类别:
-
资助金额:$17.3万
-
财政年份:--
-
负责人:Michael Henry Kutner
-
依托单位:
Biostatistics and Biomedical Informatics Core
-
批准号:8294305
-
项目类别:
-
资助金额:$20.83万
-
财政年份:--
-
负责人:Michael Henry Kutner
-
依托单位:
Biostatistics
-
批准号:7922705
-
项目类别:
-
资助金额:$19.68万
-
财政年份:--
-
负责人:Michael Henry Kutner
-
依托单位:
Biostatistical Core Data Management Core
-
批准号:8588805
-
项目类别:
-
资助金额:$23.54万
-
财政年份:--
-
负责人:Michael Henry Kutner
-
依托单位:
Biostatistical Core Data Management Core
-
批准号:8776966
-
项目类别:
-
资助金额:$18.24万
-
财政年份:--
-
负责人:Michael Henry Kutner
-
依托单位:
Biostatistical Core Data Management Core
-
批准号:8318061
-
项目类别:
-
资助金额:$24.18万
-
财政年份:--
-
负责人:Michael Henry Kutner
-
依托单位:
Biostatistics
-
批准号:8133855
-
项目类别:
-
资助金额:$19.05万
-
财政年份:--
-
负责人:Michael Henry Kutner
-
依托单位:
海外基金