NICHD NETWORKS: DATA COORDINATING CENTER

本申请书要求续签合作社五年 协议5-U01-HD19897，原标题为“绒毛取样” VS羊膜穿刺术-数据中心“。续签申请题为 “NICHD网络/幼儿保育研究：协调中心”请求 对乔治华盛顿大学生物统计中心的支持 正在开展的与国家儿童研究所有关的活动 健康与人类发展(NICHD-NIH)母胎医学股 (MFMU)和新生儿重症监护病房(NICU)网络和拟议的 与NICHD-NIH幼儿保育研究相关的活动。 NICHD MFMU和NICU网络成立于1986年，进行临床 母胎医学和流行病学方面的试验和流行病学研究 产科和新生儿医学。目前，23号 与网络相关的临床中心正在实施 共执行或分析24个项目(10个随机临床项目 试验，拟议随机临床试验的2项试点研究和12项 流行病学研究)。生物统计中心的资金来源是 MFMU和NICU网络的生物统计协调中心(BCC) 从一开始就是这样。此续签申请还包括一份建议书 由生物统计中心作为数据和统计 NICHD-NIH资助早期儿童护理协调中心(DSCC) 学习。幼儿保育研究于1991年实施，共有10个地点 对1300多名幼儿进行的观察性研究旨在检查 非产妇护理的影响，特别是在生命的第一年， 关于孩子的社交和智力发展。 生物统计中心将提供统计支持和 在设计、执行、收尾和分析领域进行咨询 当它们适用于由网络和 早期儿童保育研究。由于该计划的范围 项目，申请分为六个部分：(1)预算 网络和幼儿保育研究的合理性(2) 网络总体技术方案，(3)具体技术方案 MFMU网络方案，(4)具体技术方案 NICU网络，(5)幼儿保育研究的技术提案，以及 (6)引用文献的参考书目。

This application requests a five-year renewal of the cooperative agreement 5-U01-HD19897 previously entitled "Chorionic Villus Sampling Vs Amniocentesis - Data Center". The renewal application entitled "NICHD Networks/Early Child Care Study: Coordinating Center" requests support for The George Washington University Biostatistics Center's ongoing activities associated with the National Institute of Child Health and Human Development (NICHD-NIH) Maternal Fetal Medicine Unit (MFMU) and Neonatal Intensive Care Unit (NICU) Networks and the proposed activities associated with the NICHD-NIH Early Child Care Study. Initiated in 1986, the NICHD MFMU and NICU Networks conduct clinical trials and epidemiologic studies in maternal-fetal medicine and obstetrics, and neonatal medicine, respectively. Currently, the 23 clinical centers associated with the Networks are implementing, executing or analyzing a total of 24 projects (10 randomized clinical trials, 2 pilot studies for proposed randomized clinical trials and 12 epidemiological studies). The Biostatistics Center has been funded as the MFMU and NICU Networks' Biostatistical Coordinating Center (BCC) since its inception. This renewal application also includes a proposal by The Biostatistics Center to serve as the Data and Statistical Coordinating Center (DSCC) for the NICHD-NIH funded Early Child Care Study. Implemented in 1991, the Early Child Care Study is a 10 site observational study of over 1300 young children designed to examine the effects of nonmaternal care, especially during the first year of life, on the child's social and intellectual development. The Biostatistics Center will provide statistical support and consultation in the areas of design, execution, close-out and analysis as they apply to the program of projects conducted by the Networks and the Early Child Care Study. Due to the scope of the program of projects, the application is organized into six sections: (1) budget justification for the Networks and the Early Child Care Study, (2) general technical proposal for the Networks, (3) specific technical proposal for the MFMU Network, (4) specific technical proposal for the NICU Network, (5) technical proposal for the Early Child Care Study, and (6) bibliography of the literature cited.