REM SLEEP DYSFUNCTION IN PTSD--LIMBIC MECHANISMS

睡眠障碍，以重复的，刻板的 焦虑的梦，通常发生在创伤后应激障碍（PTSD）中。 在创伤后应激障碍的多导睡眠图研究中，我们发现了 紧张性和阶段性快速眼动（REM）睡眠作为一种可能的生物 衬底 两种类型的阶段性事件，快速眼动和腿 肌肉抽搐爆发，发生更频繁地在创伤后应激障碍的受试者相比， 年龄匹配的正常对照组。 这两项措施仍然 在随后的录音之夜，这表明， REMS阶段性事件的产生可能是睡眠的一个基本特性， 创伤后应激障碍 这些多导睡眠图数据的主要混杂因素是 酗酒史和抑郁症的共同诊断，在许多 创伤后应激障碍患者 定义PTSD的相对贡献 诊断，过去的酒精滥用和严重抑郁症，以提高REMS PTSD中阶段性事件的产生是本研究中要研究的问题。 提议 这一假设将通过三个晚上的记录来检验 一组患有PTSD的越战老兵的多导睡眠图， 一个对照组，其中一个匹配的子集将有一个历史， 酒精中毒

The disturbance of sleep, in the form of repetitive, stereotypical anxiety dreams, occurs commonly in posttraumatic stress disorder (PTSD). In polysomnographic studies of PTSD, we have identified abnormalities of tonic and phasic rapid eye movement (REM) sleep as a possible biologic substrate. Two types of phasic events, rapid eye movements and leg muscle twitch bursts, occurred more frequently in PTSD subjects compared to age-matched normal control subjects. These two measures remained elevated on a subsequent night of recording, suggesting that heightened REMS phasic event generation might be an essential property of sleep in PTSD. The major confounders of these polysomnographic data have been the history of alcohol abuse and the co-diagnosis of major depression in many of the PTSD subjects. Defining the relative contributions of the PTSD diagnosis, past alcohol abuse, and major depression to heightened REMS phasic event generation in PTSD is the problem to be investigated in this proposal. This hypothesis will be tested by recording over three nights the polysomnograms of a group of Vietnam combat veterans with PTSD and a control group, a matched subset of whom will have a history of alcoholism.