REM SLEEP DYSFUNCTION IN PTSD--LIMBIC MECHANISMS

PTSD 中的快速眼动睡眠功能障碍——边缘系统

• 批准号: 5216086
• 负责人: William S. Ball
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5216086
• 关键词: REM sleep; alcoholism /alcohol abuse; clinical research; human subject; limbic system; major depression; posttraumatic stress disorder; sleep disorders

The disturbance of sleep, in the form of repetitive, stereotypical anxiety dreams, occurs commonly in posttraumatic stress disorder (PTSD). In polysomnographic studies of PTSD, we have identified abnormalities of tonic and phasic rapid eye movement (REM) sleep as a possible biologic substrate. Two types of phasic events, rapid eye movements and leg muscle twitch bursts, occurred more frequently in PTSD subjects compared to age-matched normal control subjects. These two measures remained elevated on a subsequent night of recording, suggesting that heightened REMS phasic event generation might be an essential property of sleep in PTSD. The major confounders of these polysomnographic data have been the history of alcohol abuse and the co-diagnosis of major depression in many of the PTSD subjects. Defining the relative contributions of the PTSD diagnosis, past alcohol abuse, and major depression to heightened REMS phasic event generation in PTSD is the problem to be investigated in this proposal. This hypothesis will be tested by recording over three nights the polysomnograms of a group of Vietnam combat veterans with PTSD and a control group, a matched subset of whom will have a history of alcoholism.

睡眠障碍，以重复的、刻板的形式出现 焦虑梦，常见于创伤后应激障碍（PTSD）。 在 PTSD 的多导睡眠图研究中，我们发现了以下异常： 强直性和阶段性快速眼动 (REM) 睡眠作为一种可能的生物睡眠 基材。 两种类型的阶段性事件，快速眼球运动和腿部 与 PTSD 受试者相比，肌肉抽搐爆发的发生频率更高 至年龄匹配的正常对照受试者。 这两项措施仍 在随后的录音晚上升高，表明升高 REMS 阶段性事件的产生可能是睡眠的一个基本属性 创伤后应激障碍。 这些多导睡眠图数据的主要混杂因素是 许多人有酗酒史和重度抑郁症的共同诊断 PTSD 受试者。 定义 PTSD 的相对贡献 诊断、既往酗酒和重度抑郁症导致 REMS 增强 PTSD 中的阶段性事件生成是本研究要研究的问题 提议。 这个假设将通过三个晚上的录音来检验 一组患有创伤后应激障碍 (PTSD) 的越战老兵的多导睡眠图 对照组，其中匹配的子集将有以下病史 酗酒。