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PHASE I/II STUDY OF SNX-111 ADMINISTERED TO TERMINAL PATIENTS IN CHRONIC PAIN

PHASE I/II STUDY OF SNX-111 ADMINISTERED TO TERMINAL PATIENTS IN CHRONIC PAIN
SNX-111 用于慢性疼痛末期患者的 I/II 期研究
批准号：
5215990
负责人：
MICHAEL G BYAS-SMITH
金额：
$0.0万
依托单位：
--
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/5215990
关键词：
analgesia analgesics calcium channel blockers chronic disease /disorder clinical research clinical trial phase I drug screening /evaluation human subject human therapy evaluation pain pain threshold terminal patient care

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英文摘要
The objective of this study is to asses the safety, tolerability and analgesic effects of rising doses of SNX-111, administered intrathecally to terminally ill patients who suffer from chronic pain and have had an unsatisfactory response to opioid therapy. SNX-111 is a new type of calcium channel blocker that specifically blocks N-type neuron-specific, voltage-sensitive calcium channels which are found at presynaptic nerve terminals. This is a multicenter study, where 30 patients are expected to enroll, 5 of which will be studied at Emory. Two patients have been evaluated. The protocol is currently being modified for resubmission to the GAC.
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会议论文
PAIN RESPONSE BEFORE AND AFTER MORPHINE ADMINISTRATION
  • 批准号：
    6244371
  • 项目类别：
  • 资助金额：
    $3.62万
  • 财政年份：
    1997
  • 负责人：
    MICHAEL G BYAS-SMITH
  • 依托单位：
    EMORY UNIVERSITY
THERMAL SENSORY EFFECTS OF CAPSAICIN ON ORAL MUCOSA--NORMALS
  • 批准号：
    6244367
  • 项目类别：
  • 资助金额：
    $3.62万
  • 财政年份：
    1997
  • 负责人：
    MICHAEL G BYAS-SMITH
  • 依托单位：
    EMORY UNIVERSITY
NEUROSENSORY TESTING AND MECHANISMS OF NEUROPATHIC PAIN
  • 批准号：
    6244332
  • 项目类别：
  • 资助金额：
    $3.62万
  • 财政年份：
    1997
  • 负责人：
    MICHAEL G BYAS-SMITH
  • 依托单位：
    EMORY UNIVERSITY
PHASE I/II STUDY OF SNX-111 ADMINISTERED TO TERMINAL PATIENTS IN CHRONIC PAIN
  • 批准号：
    6244344
  • 项目类别：
  • 资助金额：
    $3.62万
  • 财政年份：
    1997
  • 负责人：
    MICHAEL G BYAS-SMITH
  • 依托单位：
    EMORY UNIVERSITY
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