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ANALYSIS OF FAMILIES WITH GENETIC SUSCEPTIBILITY TO BREAST CANCER

ANALYSIS OF FAMILIES WITH GENETIC SUSCEPTIBILITY TO BREAST CANCER
乳腺癌遗传易感性家族分析
批准号：
5216139
负责人：
SOFIA DIANA MERAJVER
金额：
$0.0万
依托单位：
--
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/5216139
关键词：
brca gene breast neoplasms clinical research family genetics gene expression gene mutation human genetic material tag human subject neoplasm /cancer genetics

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英文摘要
BRCA1, the gene responsible for familial early-onset breast and ovarian cancers, has recently been cloned. To study this gene and its mutations in women with a family history of breast cancer, we will identify 50 families with autosomal dominant transmission of breast cancer. Blood DNA and lymphocyte immortalization will be used to search for mutations and gene expression studies.
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